https://scholars.lib.ntu.edu.tw/handle/123456789/526899
Title: | Risk of incident active tuberculosis and use of corticosteroids | Authors: | Lai C.-C. Lee M.-T.G. Lee S.-H. Lee S.-H. Chang S.-S. CHIEN-CHANG LEE |
Issue Date: | 2015 | Journal Volume: | 19 | Journal Issue: | 8 | Start page/Pages: | 936-942 | Source: | International Journal of Tuberculosis and Lung Disease | Abstract: | OBJECTIVE : To examine the association between corticosteroid use and risk of active tuberculosis (TB) disease. METHODS : We conducted a population-based nested case-control study based on Taiwan's National Health Insurance Research Database between January 1999 and December 2011. Each case of incident active TB was matched to 100 controls using a risk-set sampling scheme. RESULT S : From a participant cohort of 1 million, 6229 cases of new active TB and 622 900 controls were identified. Current, recent, past, ever and chronic use of corticosteroids were associated with an increased risk of developing incident active TB, with adjusted rate ratios of respectively 2.76 (95%CI 2.44-3.11), 1.99 (95%CI 1.73-2.31), 1.17 (95%CI 1.06-1.29), 1.60 (95%CI 1.49-1.72), and 1.58 (95%CI 1.43-1.75). For subgroup analysis, the increased risk of TB in chronic corticosteroids users was substantially higher in subjects aged 670 years and female subjects. CONCLUS ION : In this relatively high TB prevalence setting, we found that use of corticosteroids was associated with an increased risk of TB. Current use of corticosteroids was associated with the highest risk of TB. ? 2015 The Union. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/526899 | ISSN: | 1027-3719 | DOI: | 10.5588/ijtld.15.0031 | SDG/Keyword: | amikacin; betamethasone; corticosteroid; cortisone; cycloserine; ethambutol; fludrocortisone; hydrocortisone; isoniazid; kanamycin; methylprednisolone; paramethasone; prednisolone; protionamide; pyrazinamide; rifampicin; streptomycin; triamcinolone; glucocorticoid; adult; Article; cohort analysis; controlled study; disease association; drug use; female; human; incidence; longitudinal study; major clinical study; male; middle aged; national health insurance; population based case control study; priority journal; reimbursement; risk assessment; risk factor; sample size; seroprevalence; social class; Taiwan; tuberculosis; age; aged; case control study; factual database; follow up; incidence; retrospective study; risk factor; sex difference; tuberculosis; Adult; Age Factors; Aged; Case-Control Studies; Databases, Factual; Female; Follow-Up Studies; Glucocorticoids; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors; Taiwan; Tuberculosis |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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