https://scholars.lib.ntu.edu.tw/handle/123456789/527087
標題: | Pathological fracture as a manifestation of extramedullary blastic crisis in chronic myelogenous leukemia: Report of one case | 作者: | HSIN-HUI YU MENG-YAO LU DONG-TSAMN LIN KAI-HSIN LIN JIH-LUH TANG SHIANN-TANG JOU |
公開日期: | 2006 | 卷: | 47 | 期: | 3 | 起(迄)頁: | 150-154 | 來源出版物: | Acta Paediatrica Taiwanica | 摘要: | A three-year-old girl with chronic myelogenous leukemia (CML) experienced a pathological fracture of her femur after a demonstrated osteolytic bone lesion. Extramedullary disease (EMD) was diagnosed following the histologic findings of a biopsy of the osteolytic lesion. Frank blast crisis in the bone marrow followed one month later. This was the youngest patient to have been reported in English literature of Philadelphia chromosome positive (Ph+) CML with isolated bony EMD and pathological fracture. Treatment with a tyrosine kinase inhibitor, imatinib mesylate (Gleevec?), in bone marrow accelerated phase of CML was failed to reverse the progression of blastic transformation, neither in the extrameditllary bone lesion nor in the bone marrow. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751252010&partnerID=40&md5=fa68af96035764b9be25d2fd244a0b02 https://scholars.lib.ntu.edu.tw/handle/123456789/527087 |
ISSN: | 1608-8115 | SDG/關鍵字: | imatinib; protein tyrosine kinase inhibitor; article; blast cell crisis; bone lesion; bone marrow; case report; chronic myeloid leukemia; disease course; female; femur fracture; histopathology; human; human tissue; leukocyte count; preschool child; Blast Crisis; Child, Preschool; Female; Femoral Fractures; Humans; Leukemia, Myeloid, Chronic; Piperazines; Pyrimidines |
顯示於: | 醫學系 |
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