https://scholars.lib.ntu.edu.tw/handle/123456789/527846
標題: | Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia | 作者: | YUNG-LI YANG Hsiao C.-C. Chen H.-Y. Lin K.-H. SHIANN-TANG JOU Chen J.-S. Chang T.-K. Sheen J.-M. SUNG-LIANG YU MENG-YAO LU Cheng C.-N. Wu K.-H. Wang S.-C. Wang J.-D. HSIU-HAO CHANG Lin S.-R. SHU-WHA LIN Lin D.-T. |
公開日期: | 2012 | 卷: | 58 | 期: | 6 | 起(迄)頁: | 846-851 | 來源出版物: | Pediatric Blood and Cancer | 摘要: | Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. ? 2011 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863353013&doi=10.1002%2fpbc.24021&partnerID=40&md5=a3d10aa8b3d7f0dbf4bc48a261c3ee79 https://scholars.lib.ntu.edu.tw/handle/123456789/527846 |
ISSN: | 1545-5009 | DOI: | 10.1002/pbc.24021 | SDG/關鍵字: | dexamethasone; DNA polymerase; prednisolone; T lymphocyte receptor gamma chain; acute lymphoblastic leukemia; age; article; cancer chemotherapy; cancer incidence; cancer patient; cancer survival; child; childhood leukemia; clinical article; controlled study; drug dose reduction; female; gene deletion; homozygous deletion; human; immunophenotyping; leukemia remission; leukocyte count; male; outcome assessment; overall survival; polymerase chain reaction; prediction; priority journal; prognosis; quantitative analysis; school child; T cell leukemia; Taiwan; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Gene Deletion; Genes, T-Cell Receptor gamma; Humans; Immunophenotyping; Induction Chemotherapy; Kaplan-Meier Estimate; Polymerase Chain Reaction; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome |
顯示於: | 醫學系 |
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