https://scholars.lib.ntu.edu.tw/handle/123456789/527846
DC Field | Value | Language |
---|---|---|
dc.contributor.author | YUNG-LI YANG | en_US |
dc.contributor.author | Hsiao C.-C. | en_US |
dc.contributor.author | Chen H.-Y. | en_US |
dc.contributor.author | Lin K.-H. | en_US |
dc.contributor.author | SHIANN-TANG JOU | en_US |
dc.contributor.author | Chen J.-S. | en_US |
dc.contributor.author | Chang T.-K. | en_US |
dc.contributor.author | Sheen J.-M. | en_US |
dc.contributor.author | SUNG-LIANG YU | en_US |
dc.contributor.author | MENG-YAO LU | en_US |
dc.contributor.author | Cheng C.-N. | en_US |
dc.contributor.author | Wu K.-H. | en_US |
dc.contributor.author | Wang S.-C. | en_US |
dc.contributor.author | Wang J.-D. | en_US |
dc.contributor.author | HSIU-HAO CHANG | en_US |
dc.contributor.author | Lin S.-R. | en_US |
dc.contributor.author | SHU-WHA LIN | en_US |
dc.contributor.author | Lin D.-T. | en_US |
dc.creator | Yang Y.-L.;Hsiao C.-C.;Chen H.-Y.;Lin K.-H.;Jou S.-T.;Chen J.-S.;Chang T.-K.;Sheen J.-M.;Yu S.-L.;Lu M.-Y.;Cheng C.-N.;Wu K.-H.;Wang S.-C.;Wang J.-D.;Hsiu-Hao Chang;Lin S.-R.;Lin S.-W.;Lin D.-T. | - |
dc.date.accessioned | 2020-12-18T05:28:43Z | - |
dc.date.available | 2020-12-18T05:28:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1545-5009 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863353013&doi=10.1002%2fpbc.24021&partnerID=40&md5=a3d10aa8b3d7f0dbf4bc48a261c3ee79 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/527846 | - |
dc.description.abstract | Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. ? 2011 Wiley Periodicals, Inc. | - |
dc.relation.ispartof | Pediatric Blood and Cancer | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | dexamethasone; DNA polymerase; prednisolone; T lymphocyte receptor gamma chain; acute lymphoblastic leukemia; age; article; cancer chemotherapy; cancer incidence; cancer patient; cancer survival; child; childhood leukemia; clinical article; controlled study; drug dose reduction; female; gene deletion; homozygous deletion; human; immunophenotyping; leukemia remission; leukocyte count; male; outcome assessment; overall survival; polymerase chain reaction; prediction; priority journal; prognosis; quantitative analysis; school child; T cell leukemia; Taiwan; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Gene Deletion; Genes, T-Cell Receptor gamma; Humans; Immunophenotyping; Induction Chemotherapy; Kaplan-Meier Estimate; Polymerase Chain Reaction; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome | - |
dc.title | Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/pbc.24021 | - |
dc.identifier.pmid | 22180181 | - |
dc.identifier.scopus | 2-s2.0-84863353013 | - |
dc.relation.pages | 846-851 | - |
dc.relation.journalvolume | 58 | - |
dc.relation.journalissue | 6 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.orcid | 0000-0002-3598-7218 | - |
crisitem.author.orcid | 0000-0003-1483-0403 | - |
crisitem.author.orcid | 0000-0003-4535-9036 | - |
crisitem.author.orcid | 0000-0003-4461-9967 | - |
crisitem.author.orcid | 0000-0003-1832-8509 | - |
crisitem.author.orcid | 0000-0001-6748-5581 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系 |
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