https://scholars.lib.ntu.edu.tw/handle/123456789/528229
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Palacios-Baena Z.R. | en_US |
dc.contributor.author | Guti?rrez-Guti?rrez B. | en_US |
dc.contributor.author | Calbo E. | en_US |
dc.contributor.author | Almirante B. | en_US |
dc.contributor.author | Viale P. | en_US |
dc.contributor.author | Oliver A. | en_US |
dc.contributor.author | Pintado V. | en_US |
dc.contributor.author | Gasch O. | en_US |
dc.contributor.author | Mart?nez-Mart?nez L. | en_US |
dc.contributor.author | Pitout J. | en_US |
dc.contributor.author | Akova M. | en_US |
dc.contributor.author | Pe?a C. | en_US |
dc.contributor.author | Molina Gil-Bermejo J. | en_US |
dc.contributor.author | Hern?ndez A. | en_US |
dc.contributor.author | Venditti M. | en_US |
dc.contributor.author | Prim N. | en_US |
dc.contributor.author | Bou G. | en_US |
dc.contributor.author | Tacconelli E. | en_US |
dc.contributor.author | Tumbarello M. | en_US |
dc.contributor.author | Hamprecht A. | en_US |
dc.contributor.author | Giamarellou H. | en_US |
dc.contributor.author | Almela M. | en_US |
dc.contributor.author | P?rez F. | en_US |
dc.contributor.author | Schwaber M.J. | en_US |
dc.contributor.author | Bermejo J. | en_US |
dc.contributor.author | Lowman W. | en_US |
dc.contributor.author | PO-REN HSUEH | en_US |
dc.contributor.author | Pa?o-Pardo J.R. | en_US |
dc.contributor.author | Torre-Cisneros J. | en_US |
dc.contributor.author | Souli M. | en_US |
dc.contributor.author | Bonomo R.A. | en_US |
dc.contributor.author | Carmeli Y. | en_US |
dc.contributor.author | Paterson D.L. | en_US |
dc.contributor.author | Pascual ?. | en_US |
dc.contributor.author | Rodr?guez-Ba?o J. | en_US |
dc.contributor.author | G?lvez J. | en_US |
dc.contributor.author | Falcone M. | en_US |
dc.contributor.author | Russo A. | en_US |
dc.contributor.author | Daikos G. | en_US |
dc.contributor.author | Trecarichi E.M. | en_US |
dc.contributor.author | Losito A.R. | en_US |
dc.contributor.author | G?mez J. | en_US |
dc.contributor.author | Iosifidis E. | en_US |
dc.contributor.author | Roilides E. | en_US |
dc.contributor.author | Karaiskos I. | en_US |
dc.contributor.author | Doi Y. | en_US |
dc.contributor.author | Tuon F.F. | en_US |
dc.contributor.author | Navarro F. | en_US |
dc.contributor.author | Mirelis B. | en_US |
dc.contributor.author | Mart?nez J.A. | en_US |
dc.contributor.author | De La Calle C. | en_US |
dc.contributor.author | Morata L. | en_US |
dc.contributor.author | San Juan R. | en_US |
dc.contributor.author | Fern?ndez-Ruiz M. | en_US |
dc.contributor.author | Larrosa N. | en_US |
dc.contributor.author | Puig M. | en_US |
dc.contributor.author | Molina J. | en_US |
dc.contributor.author | Gonz?lez V. | en_US |
dc.contributor.author | Rucci V. | en_US |
dc.contributor.author | Ruiz De Gopegui E. | en_US |
dc.contributor.author | Marinescu C.I. | en_US |
dc.contributor.author | Fari?as M.C. | en_US |
dc.contributor.author | Cano M.E. | en_US |
dc.contributor.author | Gozalo M. | en_US |
dc.contributor.author | Mora-Rillo M. | en_US |
dc.contributor.author | G?mez-Zorrilla S. | en_US |
dc.contributor.author | Tubau F. | en_US |
dc.contributor.author | Pournaras S. | en_US |
dc.contributor.author | Tsakris A. | en_US |
dc.contributor.author | Zarkotou O. | en_US |
dc.contributor.author | Azap ?.K. | en_US |
dc.contributor.author | Antoniadou A. | en_US |
dc.contributor.author | Poulakou G. | en_US |
dc.contributor.author | Virmani D. | en_US |
dc.contributor.author | Cano ?. | en_US |
dc.contributor.author | Machuca I. | en_US |
dc.contributor.author | Helvaci ?. | en_US |
dc.contributor.author | Sahin A.O. | en_US |
dc.contributor.author | Ruiz-Garbajosa P. | en_US |
dc.contributor.author | Bartoletti M. | en_US |
dc.contributor.author | Giannella M. | en_US |
dc.contributor.author | Peter S. | en_US |
dc.contributor.author | Badia C. | en_US |
dc.contributor.author | Xercavins M. | en_US |
dc.contributor.author | Fontanals D. | en_US |
dc.contributor.author | Jov? E. | en_US |
dc.creator | Palacios-Baena Z.R.;Guti?Rrez-Guti?Rrez B.;Calbo E.;Almirante B.;Viale P.;Oliver A.;Pintado V.;Gasch O.;Mart?Nez-Mart?Nez L.;Pitout J.;Akova M.;Pe?A C.;Molina Gil-Bermejo J.;Hern?Ndez A.;Venditti M.;Prim N.;Bou G.;Tacconelli E.;Tumbarello M.;Hamprecht A.;Giamarellou H.;Almela M.;P?Rez F.;Schwaber M.J.;Bermejo J.;Lowman W.;Po-Ren Hsueh;Pa?O-Pardo J.R.;Torre-Cisneros J.;Souli M.;Bonomo R.A.;Carmeli Y.;Paterson D.L.;Pascual ?.;Rodr?Guez-Ba?O J.;G?Lvez J.;Falcone M.;Russo A.;Daikos G.;Trecarichi E.M.;Losito A.R.;G?Mez J.;Iosifidis E.;Roilides E.;Karaiskos I.;Doi Y.;Tuon F.F.;Navarro F.;Mirelis B.;Mart?Nez J.A.;De La Calle C.;Morata L.;San Juan R.;Fern?Ndez-Ruiz M.;Larrosa N.;Puig M.;Molina J.;Gonz?Lez V.;Rucci V.;Ruiz De Gopegui E.;Marinescu C.I.;Fari?As M.C.;Cano M.E.;Gozalo M.;Mora-Rillo M.;G?Mez-Zorrilla S.;Tubau F.;Pournaras S.;Tsakris A.;Zarkotou O.;Azap ?.K.;Antoniadou A.;Poulakou G.;Virmani D.;Cano ?.;Machuca I.;Helvaci ?.;Sahin A.O.;Ruiz-Garbajosa P.;Bartoletti M.;Giannella M.;Peter S.;Badia C.;Xercavins M.;Fontanals D.;Jov? E. | - |
dc.date.accessioned | 2020-12-18T08:37:11Z | - |
dc.date.available | 2020-12-18T08:37:11Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/528229 | - |
dc.description.abstract | Background. There is little information about the efficacy of active alternative drugs to carbapenems except ?-lactam/?-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum ?-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems. Methods. A multinational retrospective cohort study of patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed. Cox regression including a propensity score for receiving OADs was performed to analyze 30-day all-cause mortality as main outcome. Clinical failure and length of stay were also analyzed. Results. Overall, 335 patients were included; 249 received empiric carbapenems and 86 OADs. The most frequent OADs were aminoglycosides (43 patients) and fluoroquinolones (20 patients). Empiric therapy with OADs was not associated with mortality (hazard ratio [HR], 0.75; 95% confidence interval [CI], .38-1.48) in the Cox regression analysis. Propensity score-matched pairs, subgroups, and sensitivity analyses did not show different trends; specifically, the adjusted HR for aminoglycosides was 1.05 (95% CI, .51-2.16). OADs were neither associated with 14-day clinical failure (adjusted odds ratio, 0.62; 95% CI, .29-1.36) nor length of hospital stay. Conclusions. We were unable to show that empiric treatment with OAD was associated with a worse outcome compared with carbapenems. This information allows more options to be considered for empiric therapy, at least for some patients, depending on local susceptibility patterns of ESBL-E. ? The Author 2017. | - |
dc.relation.ispartof | Clinical Infectious Diseases | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aminoglycoside; aztreonam; carbapenem; cephalosporin derivative; colistin; cotrimoxazole; doripenem; ertapenem; fosfomycin; imipenem; meropenem; quinolone derivative; tigecycline; antiinfective agent; beta lactamase; carbapenem derivative; adult; all cause mortality; antibiotic therapy; Article; bloodstream infection; clinical outcome; cohort analysis; Enterobacteriaceae infection; extended spectrum beta lactamase producing Enterobacteriaceae; female; human; length of stay; major clinical study; male; mortality rate; multicenter study; priority journal; retrospective study; bacteremia; beta-lactam resistance; drug effect; Enterobacteriaceae; enzymology; Kaplan Meier method; microbiology; middle aged; Anti-Bacterial Agents; Bacteremia; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies | - |
dc.title | Empiric Therapy with Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Results from the INCREMENT Cohort | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/cid/cix606 | - |
dc.identifier.pmid | 29020250 | - |
dc.identifier.scopus | 2-s2.0-85032746020 | - |
dc.relation.pages | 1615-1623 | - |
dc.relation.journalvolume | 65 | - |
dc.relation.journalissue | 10 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7502-9225 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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