https://scholars.lib.ntu.edu.tw/handle/123456789/528233
標題: | Bio-Kil, a nano-based disinfectant, reduces environmental bacterial burden and multidrug-resistant organisms in intensive care units | 作者: | Lee W.-S. Hsieh T.-C. Shiau J.C. Ou T.-Y. Chen F.-L. Liu Y.-H. Yen M.-Y. PO-REN HSUEH |
公開日期: | 2017 | 卷: | 50 | 期: | 5 | 起(迄)頁: | 737-746 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/Purpose This prospective before-after study was intended to investigate the effect of Bio-Kil on reducing environmental bacterial burden and healthcare-associated infections (HAIs) in intensive care units (ICUs) at the Municipal Wan-Fang Hospital, Taipei, Taiwan in 2014. Methods Four rooms in the medical and surgical ICUs were investigated and designated as study rooms (n = 2) or control rooms (n = 2). Routine disinfection was performed during the pre-intervention period in both room types. Bio-Kil was applied to the fomites and surroundings of the study rooms during the intervention period. Total bacterial burden and proportion of colonization of fomites and surroundings by multidrug-resistance organisms (MDROs) were determined before and after the intervention. The demographic characteristics, underlying conditions, and clinical outcomes of patients were analyzed. Results After application of Bio-Kil, the bacterial burden declined in both groups, although the reduction was greater in the study rooms as compared with the control rooms (p = 0.001). During the pre-intervention period, 16 patients were admitted to control rooms and 18 patients to study rooms. After the intervention, 22 patients were admitted to control rooms and 21 patients to study rooms. The number of cases of new-onset sepsis declined in the intervention group (from 33% to 23.8%), but increased in the control group (from 25% to 40.9%); however, there was no significant difference in incidence of new-onset sepsis between the study and control rooms after intervention. Conclusion Application of Bio-Kil reduced the environmental bacterial burden and MDROs in ICUs. Further studies are needed to evaluate the efficacy of this nanotechnology-based disinfectant in reducing HAIs. ? 2016 |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528233 | ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2016.04.008 | SDG/關鍵字: | 3 (trimethoxysilyl)propyloctadecyldimethyl ammonium chloride; disinfectant agent; nanomaterial; unclassified drug; disinfectant agent; aged; Article; bacterial colonization; bacterial count; bacterial load; clinical article; clinical effectiveness; clinical outcome; controlled study; demography; disinfection; female; fomite; healthcare associated infection; human; incidence; intensive care unit; male; multidrug resistance; nonhuman; outcome assessment; prospective study; sepsis; surgical ward; Taiwan; bacterial infection; bacterium; cross infection; devices; disinfection; drug effect; environmental monitoring; growth, development and aging; hospital; infection control; isolation and purification; microbiology; middle aged; multidrug resistance; nanotechnology; pathogenicity; procedures; very elderly; Aged; Aged, 80 and over; Bacteria; Bacterial Infections; Colony Count, Microbial; Cross Infection; Disinfectants; Disinfection; Drug Resistance, Multiple, Bacterial; Environmental Monitoring; Female; Hospitals; Humans; Infection Control; Intensive Care Units; Male; Middle Aged; Nanotechnology; Prospective Studies; Sepsis; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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