https://scholars.lib.ntu.edu.tw/handle/123456789/528287
標題: | Bacteremic pneumonia caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: Appropriateness of empirical treatment matters | 作者: | Cheng W.-L. PO-REN HSUEH Lee C.-C. Li C.-W. Li M.-J. Chang C.-M. Lee N.-Y. Ko W.-C. |
公開日期: | 2016 | 卷: | 49 | 期: | 2 | 起(迄)頁: | 208-215 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: Clinical information about bacteremic pneumonia caused by extended-spectrum beta-lactamase (ESBL)-producing organism is limited. Methods: A retrospective study was conducted at two medical centers in Taiwan. From May 2002 to August 2010, clinical information and outcome of adults with bacteremic pneumonia caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae were analyzed. The primary outcome is the 30-day mortality. Results: A total of 111 patients with bacteremic pneumonia caused by E. coli (37 patients, 33.3%) and K. pneumoniae (74, 66.7%) were identified. Their mean age was 69.2 years and 51.4% were male patients. Fifty-seven (51.3%) episodes were classified as hospital-acquired infections, 19 (17.1%) as health-care-associated infections, and four (3.6%) as community-acquired infections. Fifty-one (45.9%) patients received appropriate empiric antimicrobial therapy. The 30-day mortality rate was 40.5% (45 patients). In the multivariate analysis, several independent risk factors, including rapidly fatal underlying disease [odds ratio (OR), 5.75; 95% confidence interval (CI), 1.54-21.48; p = 0.009], severe sepsis (OR, 4.84; 95% CI, 1.55-15.14; p = 0.007), critical illness (OR, 4.28; 95% CI, 1.35-13.57; p = 0.013), and receipt of appropriate empirical therapy (OR, 0.19; 95% CI, 0.07-0.55; p = 0.002), were associated with 30-day mortality. The survival analysis consistently found that individuals with appropriate empiric therapy had a higher survival rate (log-rank test, p < 0.001). Conclusion: ESBL-producing bacteremic pneumonia, especially health-care-associated infections, often occurred in adults with comorbidities. Appropriate empirical therapy was associated with a favorable outcome. ? 2014. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528287 | ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2014.05.003 | SDG/關鍵字: | antiinfective agent; beta lactamase; adolescent; adult; aged; bacteremia; complication; enzymology; Escherichia coli; Escherichia coli Infections; female; human; Klebsiella Infections; Klebsiella pneumoniae; male; microbiology; middle aged; Pneumonia, Bacterial; retrospective study; secretion (process); survival analysis; Taiwan; treatment outcome; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; Escherichia coli; Escherichia coli Infections; Female; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Middle Aged; Pneumonia, Bacterial; Retrospective Studies; Survival Analysis; Taiwan; Treatment Outcome; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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