https://scholars.lib.ntu.edu.tw/handle/123456789/528314
標題: | Carbapenemase-producing Gram-negative bacteria: Current epidemics, antimicrobial susceptibility and treatment options | 作者: | Jean S.-S. Lee W.-S. Lam C. Hsu C.-W. Chen R.-J. PO-REN HSUEH |
公開日期: | 2015 | 卷: | 10 | 期: | 3 | 起(迄)頁: | 407-425 | 來源出版物: | Future Microbiology | 摘要: | Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important cause of resistance of Gram-negative bacteria. The genes encoding for the acquired carbapenemases are associated with a high potential for dissemination. In addition, infections due to Gram-negative bacteria with acquired carbapenemase production would lead to high clinical mortality rates. Of the acquired carbapenemases, Klebsiella pneumoniae carbapenemase (Ambler class A), Verona integron-encoded metallo-β-lactamase (Ambler class B), New Delhi metallo-β-lactamase (Ambler class B) and many OXA enzymes (OXA-23-like, OXA-24-like, OXA-48-like, OXA-58-like, class D) are considered to be responsible for the worldwide resistance epidemics. As compared with monotherapy with colistin or tigecycline, combination therapy has been shown to effectively lower case-fatality rates. However, development of new antibiotics is crucial in the present pandrug-resistant era. ? 2015 Future Medicine Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528314 | ISSN: | 1746-0913 | DOI: | 10.2217/FMB.14.135 | SDG/關鍵字: | antibiotic agent; aztreonam; bacterial enzyme; bacterial protein; beta lactam antibiotic; beta lactamase; carbapenem; carbapenemase; cephalosporin; clavulanic acid; cloxacillin; ertapenem; extended spectrum beta lactamase; hydrolase; imipenem; immunosuppressive agent; Klebsiella pneumoniae carbapenemase; meropenem; metallo beta lactamase; microbial enzyme; ndm enzyme; oxacillin; oxacillinase; quinolone derivative; Serratia marcescens enzyme; sulbactam; tazobactam; tigecycline; unclassified drug; unindexed drug; vim protein; antiinfective agent; bacterial protein; beta lactamase; beta-lactamase NDM-1; carbapenemase; Acinetobacter; Acinetobacter baumannii; amino acid sequence; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; bacterial gene; bacterial infection; bacterial strain; bacterium isolate; carbapenemase producing Enterobacteriaceae; Enterobacteriaceae; epidemic; fatality; gene expression; Gram negative bacterium; human; in vitro study; in vivo study; infection control; integron; Klebsiella pneumoniae; minimum inhibitory concentration; monotherapy; multidrug resistance; priority journal; Review; antibiotic resistance; drug combination; drug effects; enzymology; genetics; Gram negative bacterium; Gram-Negative Bacterial Infections; metabolism; microbial sensitivity test; microbiology; pathogenicity; Klebsiella pneumoniae; Negibacteria; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Drug Therapy, Combination; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。