https://scholars.lib.ntu.edu.tw/handle/123456789/528314
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Jean S.-S. | en_US |
dc.contributor.author | Lee W.-S. | en_US |
dc.contributor.author | Lam C. | en_US |
dc.contributor.author | Hsu C.-W. | en_US |
dc.contributor.author | Chen R.-J. | en_US |
dc.contributor.author | PO-REN HSUEH | en_US |
dc.creator | Jean S.-S.;Lee W.-S.;Lam C.;Hsu C.-W.;Chen R.-J.;Po-Ren Hsueh | - |
dc.date.accessioned | 2020-12-18T08:37:32Z | - |
dc.date.available | 2020-12-18T08:37:32Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1746-0913 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/528314 | - |
dc.description.abstract | Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important cause of resistance of Gram-negative bacteria. The genes encoding for the acquired carbapenemases are associated with a high potential for dissemination. In addition, infections due to Gram-negative bacteria with acquired carbapenemase production would lead to high clinical mortality rates. Of the acquired carbapenemases, Klebsiella pneumoniae carbapenemase (Ambler class A), Verona integron-encoded metallo-β-lactamase (Ambler class B), New Delhi metallo-β-lactamase (Ambler class B) and many OXA enzymes (OXA-23-like, OXA-24-like, OXA-48-like, OXA-58-like, class D) are considered to be responsible for the worldwide resistance epidemics. As compared with monotherapy with colistin or tigecycline, combination therapy has been shown to effectively lower case-fatality rates. However, development of new antibiotics is crucial in the present pandrug-resistant era. ? 2015 Future Medicine Ltd. | - |
dc.relation.ispartof | Future Microbiology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antibiotic agent; aztreonam; bacterial enzyme; bacterial protein; beta lactam antibiotic; beta lactamase; carbapenem; carbapenemase; cephalosporin; clavulanic acid; cloxacillin; ertapenem; extended spectrum beta lactamase; hydrolase; imipenem; immunosuppressive agent; Klebsiella pneumoniae carbapenemase; meropenem; metallo beta lactamase; microbial enzyme; ndm enzyme; oxacillin; oxacillinase; quinolone derivative; Serratia marcescens enzyme; sulbactam; tazobactam; tigecycline; unclassified drug; unindexed drug; vim protein; antiinfective agent; bacterial protein; beta lactamase; beta-lactamase NDM-1; carbapenemase; Acinetobacter; Acinetobacter baumannii; amino acid sequence; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; bacterial gene; bacterial infection; bacterial strain; bacterium isolate; carbapenemase producing Enterobacteriaceae; Enterobacteriaceae; epidemic; fatality; gene expression; Gram negative bacterium; human; in vitro study; in vivo study; infection control; integron; Klebsiella pneumoniae; minimum inhibitory concentration; monotherapy; multidrug resistance; priority journal; Review; antibiotic resistance; drug combination; drug effects; enzymology; genetics; Gram negative bacterium; Gram-Negative Bacterial Infections; metabolism; microbial sensitivity test; microbiology; pathogenicity; Klebsiella pneumoniae; Negibacteria; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Drug Therapy, Combination; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests | - |
dc.title | Carbapenemase-producing Gram-negative bacteria: Current epidemics, antimicrobial susceptibility and treatment options | en_US |
dc.type | review | en |
dc.identifier.doi | 10.2217/FMB.14.135 | - |
dc.identifier.pmid | 25812463 | - |
dc.identifier.scopus | 2-s2.0-84926153992 | - |
dc.relation.pages | 407-425 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7502-9225 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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