https://scholars.lib.ntu.edu.tw/handle/123456789/528315
Title: | Clinical implications of species identification in monomicrobial Aeromonas bacteremia | Authors: | Wu C.-J. Chen P.-L. PO-REN HSUEH Chang M.-C. Tsai P.-J. Shih H.-I. Wang H.-C. Chou P.-H. Ko W.-C. |
Issue Date: | 2015 | Journal Volume: | 10 | Journal Issue: | 2 | Source: | PLoS ONE | Abstract: | Background: Advances in Aeromonas taxonomy have led to the reclassification of aeromonads. Hereon, we aimed to re-evaluate the characteristics of Aeromonas bacteremia, including those of a novel species, Aeromonas dhakensis. Methodology/Principal Findings: A retrospective study of monomicrobial Aeromonas bacteremia at a medical center in southern Taiwan from 2004-2011 was conducted. Species identification was based on rpoB sequencing. Of bacteremia of 153 eligible patients, A. veronii (50 isolates, 32.7%), A. dhakensis (48, 31.4%), A. caviae (43, 28.1%), and A. hydrophila (10, 6.5%) were the principal causative species. A. dhakensis and A. veronii bacteremia were mainly community-acquired and presented as primary bacteremia, spontaneous bacterial peritonitis, or skin and soft-tissue infection, whereas A. caviae was associated with hospital-onset bacteremia. The distribution of the AmpC β-lactamase and metallo-β-lactamase genes was species-specific: blaAQU-1, blaMOX, or blaCepH was present in A. dhakensis, A. caviae, or A. hydrophila, respectively, and blaCphA was present in A. veronii, A. dhakensis, and A. hydrophila. The cefotaxime resistance rates of the A. caviae, A. dhakensis, and A. hydrophila isolates were higher than that of A. veronii (39.5%%, 25.0%, and 30% vs. 2%, respectively). A. dhakensis bacteremia was linked to the highest 14-day sepsis-related mortality rate, followed by A. hydrophila, A. veronii, and A. caviae bacteremia (25.5%, 22.2%, 14.0%, and 4.7%, respectively; P = 0.048). Multivariate analysis revealed that A. dhakensis bacteremia, active malignancies, and a Pitt bacteremia score ? 4 was an independent mortality risk factor. Conclusions/Significance: Characteristics of Aeromonas bacteremia vary between species. A. dhakensis prevalence and its associated poor outcomes suggest it an important human pathogen. ? 2015 Wu et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528315 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0117821 | SDG/Keyword: | cefotaxime; ceftazidime; ceftriaxone; cephalosporin; AmpC beta-lactamases; antiinfective agent; bacterial protein; beta lactamase; adult; Aeromonas; Aeromonas caviae; Aeromonas dhakensis; Aeromonas hydrophila; Aeromonas veronii; antibiotic resistance; antibiotic sensitivity; Article; bacteremia; bacterial gene; bacterium identification; blaAQU 1 gene; blaCepH gene; blaMOX 6 gene; controlled study; human; mortality; nonhuman; retrospective study; rpoB gene; survival rate; aged; bacteremia; classification; comorbidity; drug effects; female; genetics; Gram-Negative Bacterial Infections; male; microbial sensitivity test; microbiology; middle aged; treatment outcome; Aeromonas; Aeromonas hydrophila; Aeromonas veronii; Bacteria (microorganisms); Adult; Aeromonas; Aged; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; beta-Lactamases; Comorbidity; Female; Gram-Negative Bacterial Infections; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; Treatment Outcome |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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