https://scholars.lib.ntu.edu.tw/handle/123456789/528382
標題: | Trends in the antimicrobial susceptibilities and serotypes of Streptococcus pneumoniae: Results from the Tigecycline in Vitro Surveillance in Taiwan (TIST) study, 2006-2010 | 作者: | Tsai H.-Y. Chen Y.-H. Liao C.-H. Lu P.-L. Huang C.-H. Lu C.-T. Chuang Y.-C. Tsao S.-M. Chen Y.-S. Liu Y.-C. Chen W.-Y. Jang T.-N. Lin H.-C. Chen C.-M. Shi Z.-Y. SUNG-CHING PAN Yang J.-L. HSIANG-CHI KUNG Liu C.-E. Cheng Y.-J. Liu J.-W. Sun W. Wang L.-S. Ko W.-C. Yu K.-W. Chiang P.-C. Lee M.-H. Lee C.-M. Hsu G.-J. PO-REN HSUEH |
公開日期: | 2013 | 卷: | 42 | 期: | 4 | 起(迄)頁: | 312-316 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | Isolates of Streptococcus pneumoniae (n = 530) were collected from 20 hospitals in different parts of Taiwan from 2006 to 2010. MICs to 16 antimicrobial agents were determined by broth dilution method and serotypes were identified by latex agglutination. Based on meningitis (non-meningitis) criteria established by the CLSI, 11.7% (63.2%) of all isolates were susceptible to penicillin and 46.0% (83.8%) were susceptible to ceftriaxone. Of the isolates, 94.3% were non-susceptible to azithromycin and 5.8% and 7.2% were non-susceptible to moxifloxacin and levofloxacin, respectively. Susceptibility to penicillin by meningitis criteria increased significantly (P = 0.0012) with year, and that to clindamycin and amoxicillin/clavulanic acid declined significantly (P < 0.05). Six major serotypes were found, namely 19F (24.0%), 23F (18.5%), 14 (13.6%), 6B (12.5%), 19A (7.5%) and 3 (5.1%). Prevalence of serotypes 19F and 14 remained stationary, that of serotype 6B decreased significantly (P < 0.0001) and that of serotype 19A increased significantly (P < 0.0001) with year. The coverage rate of PCV-7 among the pneumococcal isolates declined from 80.5% in 2006 to 50% in 2010 (P < 0.0001) and that of PCV-13 declined from 91.5% in 2009 to 75% in 2010. The non-susceptibility rate to levofloxacin was highest among serotype 23F isolates (13.3%) and lowest among serotype 19A isolates (2.5%). Rates of resistance to the four agents penicillin, ceftriaxone, azithromycin and clindamycin were highest among serotype 19A isolates (70.0%) and 23F isolates (49.0%). All serotype 3 isolates were susceptible to four of the most commonly used antibiotics (penicillin, ceftriaxone, azithromycin and levofloxacin). ? 2013 Elsevier B.V. and the International Society of Chemotherapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528382 | ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2013.05.013 | SDG/關鍵字: | amoxicillin; azithromycin; ceftriaxone; clavulanic acid; clindamycin; levofloxacin; moxifloxacin; penicillin derivative; tigecycline; antibiotic sensitivity; article; bacterium identification; bacterium isolate; broth dilution; controlled study; in vitro study; latex agglutination test; meningitis; minimum inhibitory concentration; nonhuman; priority journal; serotype; Streptococcus pneumoniae; Taiwan; trend study; upregulation; Antimicrobial susceptibility; Serotypes; Streptococcus pneumoniae; Taiwan; TIST; Anti-Bacterial Agents; Drug Resistance, Bacterial; Epidemiological Monitoring; Hospitals; Humans; Latex Fixation Tests; Microbial Sensitivity Tests; Minocycline; Pneumococcal Infections; Pneumococcal Vaccines; Serotyping; Streptococcus pneumoniae; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。