https://scholars.lib.ntu.edu.tw/handle/123456789/528539
標題: | Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: An ANSORP study | 作者: | Song J.-H. PO-REN HSUEH Chung D.R. Ko K.S. Kang C.-I. Peck K.R. Yeom J.-S. Kim S.-W. Chang H.-H. Kim Y.-S. Jung S.-I. Son J.S. Man-Kit So T. Lalitha M.K. Yang Y. Huang S.-G. Wang H. Lu Q. Carlos C.C. Perera J.A. Chiu C.-H. Liu J.-W. Chongthaleong A. Thamlikitkul V. Hung Van P. |
公開日期: | 2011 | 卷: | 66 | 期: | 5 | 起(迄)頁: | 1061-1069 | 來源出版物: | Journal of Antimicrobial Chemotherapy | 摘要: | Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals in many Asian countries. Recent emergence of community-associated (CA) MRSA worldwide has added another serious concern to the epidemiology of S. aureus infections. To understand the changing epidemiology of S. aureus infections in Asian countries, we performed a prospective, multinational surveillance study with molecular typing analysis. Methods: We evaluated the prevalence of methicillin resistance in S. aureus isolates in CA and healthcareassociated (HA) infections, and performed molecular characterization and antimicrobial susceptibility tests of MRSA isolates. Results: MRSA accounted for 25.5% of CA S. aureus infections and 67.4% of HA infections. Predominant clones of CA-MRSA isolates were ST59-MRSA-SCCmec type IV-spa type t437, ST30-MRSA-SCCmec type IV-spa type t019 and ST72-MRSA-SCCmec type IV-spa type t324. Previously established nosocomial MRSA strains including sequence type (ST) 239 and ST5 clones were found among CA-MRSA isolates from patients without any risk factors for HA-MRSA infection. CA-MRSA clones such as ST59, ST30 and ST72 were also isolated from patients with HA infections. Conclusions: Our findings confirmed that MRSA infections in the community have been increasing in Asian countries. Data also suggest that various MRSA clones have spread between the community and hospitals as well as between countries. ? The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528539 | ISSN: | 0305-7453 | DOI: | 10.1093/jac/dkr024 | SDG/關鍵字: | adult; antibiotic sensitivity; article; Asia; bacterium isolate; clone; community; community associated infection; controlled study; disease surveillance; female; health care associated infection; hospital; human; infection; major clinical study; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; molecular typing; prospective study; risk assessment; Adolescent; Adult; Aged; Aged, 80 and over; Asia; Bacterial Typing Techniques; Child; Child, Preschool; Community-Acquired Infections; Cross Infection; Female; Humans; Infant; International Cooperation; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Molecular Epidemiology; Molecular Typing; Prevalence; Prospective Studies; Staphylococcal Infections; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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