https://scholars.lib.ntu.edu.tw/handle/123456789/528774
標題: | Assessment of Platelia Aspergillus enzyme immunoassay for the diagnosis of invasive aspergillosis | 作者: | Lai C.-C. Hsu H.-L. LI-NA LEE PO-REN HSUEH |
公開日期: | 2007 | 卷: | 40 | 期: | 2 | 起(迄)頁: | 148-153 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background and Purpose: This study investigated the diagnostic value of Platelia Aspergillus enzyme immunoassay (EIA) for galactomannan (GM) antigen in patients at risk of invasive aspergillosis (IA), and its association with clinical course and outcome. Methods: A total of 304 blood samples were collected from 189 patients at risk of IA during a 1-year period at a tertiary referral center. Classification of IA was made on the basis of the European Organization for Research and Treatment of Cancer case definitions. Results: Of the 189 patients, 5 had proven IA, 9 had probable IA, 26 had possible IA, and 149 had no IA. Diagnostic levels of GM were detected in 80% of proven and in 77% of probable IA cases. The overall sensitivity, specificity, and positive and negative predictive values for this assay, using a 1.5 index cut-off value, were 78.6%, 93.9%, 55.0%, and 97.9%, respectively. With the 0.5 index cut-off value, the sensitivity would increase to 100%. A close relationship was found between clinical course and the kinetics of GM indices in survivors. Conclusions: The Platelia Aspergillus EIA is a useful screening test for the detection of IA. Regular monitoring of the kinetics of GM-EIA indices is a useful predictor of clinical course and outcome. ? 2007 Journal of Microbiology, Immunology and Infection. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528774 | ISSN: | 1684-1182 | SDG/關鍵字: | adolescent; adult; aged; article; aspergillosis; Aspergillus; blood sampling; cancer classification; controlled study; diagnostic accuracy; diagnostic value; disease course; enzyme immunoassay; female; human; major clinical study; male; school child; sensitivity and specificity; treatment outcome; Adult; Aged; Antigens, Fungal; Aspergillosis; Aspergillus; Child; Female; Humans; Immunoenzyme Techniques; Kinetics; Male; Mannans; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; Time Factors |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。