https://scholars.lib.ntu.edu.tw/handle/123456789/529237
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | PI-CHUAN FAN | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.contributor.author | PING-ING LEE | en_US |
dc.contributor.author | Safary A. | en_US |
dc.contributor.author | Lee C.-Y. | en_US |
dc.date.accessioned | 2020-12-21T01:58:27Z | - |
dc.date.available | 2020-12-21T01:58:27Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031986247&doi=10.1016%2fS0264-410X%2897%2900179-5&partnerID=40&md5=ea861b0d4e0f4f3f47aa8e0fe42a075d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/529237 | - |
dc.description.abstract | Long-term persistence of hepatitis A virus (HAV) serum antibody in vaccinated children has not been demonstrated in previous studies. To study the long-term immunogenicity to HAV vaccine, three doses of strain HM 175 HAV vaccine with 360 enzyme-linked immunosorbent assay units were administered to 107 children, aged from 1.0 to 6.8 years, at 0, 1 and 6 months. The administration of one vaccine dose induced seropositivity (anti-HAV titer ? 20 mIU ml-1) in 95% of all vaccinees at month 1. All subjects remained seropositive until month 6. The titers of HAV antibody remained above 20 mIU ml-1 in all subjects followed up to 60 months. The geometric mean titer (GMT) reached its peak (3802 mIU ml-1) at month 7, i.e. 1 month after the booster dose, and then declined until the end of follow-up at month 60 (661 mIU ml-1). A trend of higher GMT in female subjects persisted up to month 60. The changes of the GMT over time were best described by the regression equation: log (GMT) = 3.26 - 0.08 x (age in years) (r = -0.95, P = 0.014). According to this equation, the geometric mean concentration would reach 20 mIU ml-1 at around 24.5 years after the beginning of vaccination. In conclusion, those who completed the recommended three-dose inactivated HAV vaccination series remained seroprotective for at least 5 years. Theoretically, such a vaccination program can provide a protective period of over 20 years in children. This paper may be the first to describe at least 5 years. Theoretically, such a vaccination program can provide a protective period of over 20 years in children. This paper may be the first to describe at least 5-year immunogenicity of inactivated HAV vaccination in healthy children. | - |
dc.relation.ispartof | Vaccine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis a vaccine; antibody blood level; antibody titer; article; child; controlled study; enzyme linked immunosorbent assay; follow up; hepatitis a; hepatitis a virus; human; immunogenicity; major clinical study; priority journal; taiwan; vaccination; Child; Child, Preschool; Female; Hepatitis A Vaccines; Hepatitis A Virus, Human; Humans; Immunization Programs; Infant; Male; Sex Factors; Taiwan; Time Factors; Vaccines, Inactivated; Viral Hepatitis Vaccines | - |
dc.title | Follow-up immunogenicity of an inactivated hepatitis A virus vaccine in healthy children: Results after 5 years | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0264-410X(97)00179-5 | - |
dc.identifier.pmid | 9607035 | - |
dc.identifier.scopus | 2-s2.0-0031986247 | - |
dc.relation.pages | 232-235 | - |
dc.relation.journalvolume | 16 | - |
dc.relation.journalissue | 2月3日 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-6974-971X | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.orcid | 0000-0002-7299-2825 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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