https://scholars.lib.ntu.edu.tw/handle/123456789/530005
標題: | Increased levels of tissue plasminogen activator antigen and factor VIII activity in nonvalvular atrial fibrillation: Relation to predictors of thromboembolism | 作者: | TZUNG-DAU WANG WEN-JONE CHEN Su S.S.Y.I. Su T.A.C. MING-FONG CHEN Liau C.-S. Yuan-Teh L.E.E. |
公開日期: | 2001 | 卷: | 12 | 期: | 8 | 起(迄)頁: | 877-884 | 來源出版物: | Journal of Cardiovascular Electrophysiology | 摘要: | Introduction: Given that nonvalvular atrial fibrillation (AF)-associated stroke can be either cardioembolic or atherothrombotic, we investigated the relationships between nonvalvular AF and hemostatic factors reflecting intrinsic thrombogenic and atherogenic potentials (tissue plasminogen activator [t-PA] antigen, plasminogen activator inhibitor-1, and factor VIII activity). We also evaluated the clinical applicability of these hemostatic factors by examining whether AF subjects with established clinical or echocardiographic predictors of thromboembolism had higher levels of these factors. Methods and Results: Of the 3,212 participants of a Chinese population-based study, 53 subjects (1.7%) with AF were identified. Among the hemostatic factors measured, t-PA antigen (median 12.8 vs 8.1 ng/mL; P < 0.01) and factor VIII activity (median 155% vs 133%; P < 0.05) were significantly higher in AF subjects after adjustment for age and sex. In multivariate analysis, features independently associated with t-PA antigen levels were AF, age, sex, body mass index, systolic blood pressure, total cholesterol, triglycerides, and left ventricular systolic dysfunction. Features independently associated with factor VIII activity levels included AF, age, and total cholesterol. Levels of both t-PA antigen and factor VIII activity were primarily elevated in AF subjects with predictors of thromboembolism (age >75 years, hypertension, diabetes, and left ventricular systolic dysfunction), whereas in AF subjects with no thromboembolic predictors, plasma levels of hemostatic factors examined were similar to those without AF. Conclusion: We demonstrated that nonvalvular AF was independently associated with increased peripheral levels of t-PA antigen and factor VIII activity. Levels of both hemostatic factors were primarily elevated in AF subjects with predictors of thromboembolism. Whether these hemostatic factors are independently predictive of future thromboembolic events in AF patients requires further investigation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/530005 | ISSN: | 1045-3873 | DOI: | 10.1046/j.1540-8167.2001.00877.x | SDG/關鍵字: | blood clotting factor 8; cholesterol; plasminogen activator inhibitor 1; tissue plasminogen activator; triacylglycerol; adult; age; aged; antigen detection; article; body mass; Chinese; cholesterol blood level; diabetes mellitus; female; heart atrium fibrillation; hemostasis; human; hypercoagulability; hypertension; major clinical study; male; population research; prediction; priority journal; risk factor; sex difference; systolic blood pressure; thromboembolism; triacylglycerol blood level |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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