https://scholars.lib.ntu.edu.tw/handle/123456789/530108
標題: | High-volume continuous venovenous hemofiltration as an effective therapy for acute management of inborn errors of metabolism in young children | 作者: | Lai Y.-C. Huang H.-P. I-JUNG TSAI Tsau Y.-K. |
關鍵字: | Hemodialysis; Hemofiltration; Hyperammonemia; Organic acidemia; Peritoneal dialysis | 公開日期: | 2007 | 卷: | 25 | 期: | 4 | 起(迄)頁: | 303-308 | 來源出版物: | Blood Purification | 摘要: | Background/Aim: Renal replacement therapies (RRTs) have been used for the acute management of inborn errors of metabolism. Hemodialysis is the most effective modality. The aim of this article is to demonstrate that high-volume hemofiltration can offer an alternative way to effectively remove small molecules. Methods: Eight patients presented with acute neurological deterioration due to ammonia or organic acid accumulation. Different RRTs were applied, including continuous venovenous hemofiltration (CVVH, n = 7), continuous arteriovenous hemofiltration (CAVH, n = 2), continuous venovenous hemodialysis (CVVHD, n = 1), intermittent hemodialysis (HD, n = 1), and peritoneal dialysis (PD, n = 2). Results: Ammonia 50% reduction time in HD was 1.7 h while in CVVH it was 2-14.5 h. The greater the ultrafiltration flow was, the sooner patients regained consciousness. CAVH, CVVHD or PD was not sufficient enough. Conclusion: CVVH also has a good clearance for organic acid and ammonia if applying high-volume hemofiltration (>35 ml/kg/h). It can be therefore be considered as an alternative therapy if infant HD is not available. Copyright ? 2007 S. Karger AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34548855112&doi=10.1159%2f000106102&partnerID=40&md5=7863b5be226f8b37ab95f33ffc1000ca https://scholars.lib.ntu.edu.tw/handle/123456789/530108 |
ISSN: | 0253-5068 | DOI: | 10.1159/000106102 | SDG/關鍵字: | ammonia; carboxylic acid; alternative medicine; article; child; clinical article; consciousness level; continuous hemodiafiltration; continuous hemofiltration; controlled study; female; hemodialysis; human; inborn error of metabolism; male; neurologic disease; newborn; peritoneal dialysis; priority journal; renal replacement therapy; ultrafiltration; Carbamoyl-Phosphate Synthase I Deficiency Disease; Child; Child, Preschool; Female; Hemofiltration; Humans; Hyperammonemia; Infant; Infant, Newborn; Infection; Male; Maple Syrup Urine Disease; Metabolism, Inborn Errors; Methylmalonic Acid; Ornithine Carbamoyltransferase Deficiency Disease; Renal Replacement Therapy; Treatment Outcome |
顯示於: | 醫學系 |
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