https://scholars.lib.ntu.edu.tw/handle/123456789/531014
標題: | Genome-wide gene expression analysis implicates the immune response and lymphangiogenesis in the pathogenesis of fetal chylothorax | 作者: | Yeang C.-H. Ma G.-C. JIN-CHUNG SHIH YU-SHIH YANG Chen C.-P. Chang S.-P. Wu S.-H. Liu C.-S. Kuo S.-J. HUNG-CHIEH CHOU WUH-LIANG HWU Cameron A.D. Ginsberg N.A. Lin Y.-S. Chen M. |
公開日期: | 2012 | 卷: | 7 | 期: | 4 | 起(迄)頁: | e34901 | 來源出版物: | PLoS ONE | 摘要: | Fetal chylothorax (FC) is a rare condition characterized by lymphocyte-rich pleural effusion. Although its pathogenesis remains elusive, it may involve inflammation, since there are increased concentrations of proinflammatory mediators in pleural fluids. Only a few hereditary lymphedema-associated gene loci, e.g. VEGFR3, ITGA9 and PTPN11, were detected in human fetuses with this condition; these cases had a poorer prognosis, due to defective lymphangiogenesis. In the present study, genome-wide gene expression analysis was conducted, comparing pleural and ascitic fluids in three hydropic fetuses, one with and two without the ITGA9 mutation. One fetus (the index case), from a dizygotic pregnancy (the cotwin was unaffected), received antenatal OK-432 pleurodesis and survived beyond the neonatal stage, despite having the ITGA9 mutation. Genes and pathways involved in the immune response were universally up-regulated in fetal pleural fluids compared to those in ascitic fluids. Furthermore, genes involved in the lymphangiogenesis pathway were down-regulated in fetal pleural fluids (compared to ascitic fluid), but following OK-432 pleurodesis, they were up-regulated. Expression of ITGA9 was concordant with overall trends of lymphangiogenesis. In conclusion, we inferred that both the immune response and lymphangiogenesis were implicated in the pathogenesis of fetal chylothorax. Furthermore, genome-wide gene expression microarray analysis may facilitate personalized medicine by selecting the most appropriate treatment, according to the specific circumstances of the patient, for this rare, but heterogeneous disease. ? 2012 Yeang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859978284&doi=10.1371%2fjournal.pone.0034901&partnerID=40&md5=3a20ee1485a32a7849ccd3d4e6ed7217 https://scholars.lib.ntu.edu.tw/handle/123456789/531014 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0034901 | SDG/關鍵字: | picibanil; article; ascites fluid; case report; chylothorax; dizygotic twins; down regulation; female; fetal chylothorax; fetus; fetus hydrops; gene; gene expression; gene mutation; human; immune response; Itga9 gene; lymphangiogenesis; microarray analysis; nucleotide sequence; pathogenesis; pleura fluid; pleurodesis; protein expression; upregulation |
顯示於: | 醫學系 |
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