https://scholars.lib.ntu.edu.tw/handle/123456789/531290
標題: | Low-density lipoprotein cholesterol: Association with mortality and hospitalization in hemodialysis patients | 作者: | CHIH-KANG CHIANG Ho T.-I. Hsu S.-P. Peng Y.-S. Pai M.-F. SHAO-YU YANG KUAN-YU HUNG TUN-JUN TSAI |
公開日期: | 2005 | 卷: | 23 | 期: | 2 | 起(迄)頁: | 134-140 | 來源出版物: | Blood Purification | 摘要: | Background/Aims: Hypocholesterolemia is a common finding in hospitalized elderly people, critically ill surgical patients, septic patients and end-stage renal disease patients. The different effect of lipid subfractions on patients with end-stage renal disease has never been demonstrated. We aim to study the effect of lipid subfractions on hospitalization and mortality in maintenance hemodialysis (MHD) patients. Methods: Lipid subfractions, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured in 210 patients with MHD in a single dialysis center. Patients were stratified into three groups based on the tertiles of lipid levels, and differences in patient characteristics and survival were evaluated. Results: Of a total of 22 deceased patients in our MHD cohort, infection-related mortality (50%) was higher than cardiovascular-related mortality (18.2%). Significant differences (p < 0.05) in the duration and frequency of hospitalization and in mortality events were observed when patients were divided into different subgroups according to the tertiles of baseline TC and LDL-C levels. Patients with lower LDL had significantly lower levels of albumin, TC and TG. The LDL-C tertiles were similar in terms of age, hypertension, diabetes, biochemical results, hematocrit, adequacy of hemodialysis and normalized protein catabolism rate. Both TC and LDL-C predicted survival (p < 0.001), but not TG and HDL-C in the Kaplan-Meier model. The Cox proportional hazard model demonstrated that baseline serum LDL-C was the best lipid subfraction in predicting all-cause death with an adjusted hazard ratio (95% confidence interval) for each 10 mg/dl of 0.752 (0.631-0.898; p = 0.002). Conclusions: We firstly demonstrated that lipid subfractions, including TC and LDL-C, predict poor outcomes in a MHD cohort with high infection-related mortality. Copyright ? 2005 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-16344366601&doi=10.1159%2f000083529&partnerID=40&md5=d943d9a4ee79fe3c6607af0f90be3ead https://scholars.lib.ntu.edu.tw/handle/123456789/531290 |
ISSN: | 0253-5068 | DOI: | 10.1159/000083529 | SDG/關鍵字: | albumin; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; age distribution; albumin blood level; article; cause of death; cholesterol blood level; cohort analysis; confidence interval; controlled study; diabetes mellitus; dialysis; disease duration; female; hazard assessment; hematocrit; hemodialysis; hospitalization; human; hypertension; hypocholesterolemia; infection complication; Kaplan Meier method; lipid analysis; major clinical study; male; mortality; priority journal; protein degradation; survival rate; triacylglycerol blood level; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cause of Death; Cholesterol, LDL; Female; Hospitalization; Humans; Infection; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Mortality; Proportional Hazards Models; Renal Dialysis; Survival Analysis |
顯示於: | 醫學系 |
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