https://scholars.lib.ntu.edu.tw/handle/123456789/531546
標題: | Associations between long-term particulate matter exposure and adult renal function in the taipei metropolis | 作者: | Yang Y.-R. YUNG-MING CHEN Chen S.-Y. CHANG-CHUAN CHAN |
公開日期: | 2017 | 出版社: | Public Health Services, US Dept of Health and Human Services | 卷: | 125 | 期: | 4 | 起(迄)頁: | 602-607 | 來源出版物: | Environmental Health Perspectives | 摘要: | Background: Studies on the effect of air pollutions on kidney diseases are still limited. Objective: We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. Methods: We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m2 were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter < 10 μm (PM10), coarse particles (PMCoarse), fine particles (PM2.5), and PM2.5Absorbance. Generalized linear and logistic regression models were used to estimate the associations between PM exposure and renal function. Results: An IQR increase in PM10 (5.83 μg/m3) was negatively associated with eGFR by –0.69 (95% CI: –0.89, –0.48) mL/min/1.73 m2 and positively associated with the prevalence of CKD with adjusted OR = 1.15 (95% CI: 1.07, 1.23). An IQR increase in PMCoarse (6.59 μg/m3) was significantly associated with lower eGFR by –1.07 (95% CI: –1.32, –0.81) mL/min/1.73 m2 and CKD with OR = 1.26 (95% CI: 1.15, 1.38). In contrast, neither outcome was significantly associated with PM2.5 or PM2.5Absorbance. Stratified analyses indicated that associations of CKD with both PM10 and PMCoarse were limited to participants < 65 years of age, and were stronger (for PM10) or limited to (PMCoarse) women. Associations also appeared to be stronger in those without (vs. with) hypertension, and in normal versus overweight participants. Conclusions: Exposure during the previous year to PM10 and PMCoarse, but not PM2.5 or PM2.5Absorbance, was associated with reduced renal function among Taiwanese adults. © 2017, Public Health Services, US Dept of Health and Human Services. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016783601&doi=10.1289%2fEHP302&partnerID=40&md5=4087d42663460cd93e94ad82da82cd32 https://scholars.lib.ntu.edu.tw/handle/123456789/531546 |
ISSN: | 0091-6765 | DOI: | 10.1289/EHP302 | SDG/關鍵字: | adult; age; aged; air pollution; alcohol consumption; Article; chronic kidney failure; diabetes mellitus; educational status; estimated glomerular filtration rate; female; gender; geographic distribution; human; hyperlipidemia; hypertension; kidney function; long term exposure; major clinical study; male; obesity; particulate matter; priority journal; questionnaire; smoking; air pollutant; air pollution; analysis; environmental exposure; Renal Insufficiency, Chronic; statistical model; statistics and numerical data; Taiwan; theoretical model; air pollutant; particulate matter; Air Pollutants; Air Pollution; Environmental Exposure; Humans; Logistic Models; Models, Theoretical; Particulate Matter; Renal Insufficiency, Chronic; Taiwan |
顯示於: | 醫學系 |
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