https://scholars.lib.ntu.edu.tw/handle/123456789/531640
標題: | Outcomes of stage 3-5 chronic kidney disease before end-stage renal disease at a single center in Taiwan | 作者: | Chiu Y.-L. KUO-LIONG CHIEN SHUEI-LIONG LIN YUNG-MING CHEN TUN-JUN TSAI KWAN-DUN WU |
公開日期: | 2008 | 卷: | 109 | 期: | 3 | 起(迄)頁: | c109-c118 | 來源出版物: | Nephron - Clinical Practice | 摘要: | Background: Taiwan has the highest incidence of end-stage renal disease (ESRD) in the world, but little is known about the outcomes of patients with chronic kidney disease (CKD) before ESRD in Taiwan. This study investigated the rate of renal progression and predictors for ESRD and death in a prospective cohort of patients under usual nephrologic care at a single center. Methods: A total of 433 patients at CKD stage 3-5 short of dialysis were recruited from nephrology clinics. Patients were monitored for up to 36 months or until ESRD, death or loss to follow-up. Glomerular filtration rates (GFR) were calculated by the Modification of Diet in Renal Disease abbreviated formula. Results: At baseline, mean age was 65.6 years, 61.7% were male, 33.3% were diabetic and 29.1% had cardiovascular diseases (CVD). At the end of follow-up, 123 patients (28.4%) had advanced to ESRD and 41 (9.5%) had died. Mean annual declines in GFR were 2.24, 4.22, and 3.23 ml/min/1.73 m2 for stages 3, 4, and 5, respectively. By Cox regression model, patients with CVD, lower BMI and higher systolic BP were more likely to develop ESRD. Older patients with CVD and lower systolic BP were more likely to die. Conclusion: In this CKD cohort, patients were more likely to develop ESRD than cardiovascular death. The rate of GFR decline and predictors of ESRD were comparable to those reported in Western countries. Thus, the high incidence of ESRD in Taiwan may be attributed, at least in part, to lower cardiovascular mortality. Copyright ? 2008 S. Karger AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-47949103772&doi=10.1159%2f000145453&partnerID=40&md5=fb5d3211e239b9065c1469580c4ad4a5 https://scholars.lib.ntu.edu.tw/handle/123456789/531640 |
ISSN: | 1660-2110 | DOI: | 10.1159/000145453 | SDG/關鍵字: | angiotensin receptor antagonist; antilipemic agent; dipeptidyl carboxypeptidase inhibitor; adult; aged; article; body mass; cardiovascular disease; cardiovascular risk; chronic kidney disease; cohort analysis; death; diabetes mellitus; dialysis; disease course; female; follow up; glomerulus filtration rate; human; incidence; kidney failure; major clinical study; male; mortality; multivariate analysis; nephrologist; nephrology; patient care; patient monitoring; predictor variable; priority journal; proportional hazards model; prospective study; systolic blood pressure; Taiwan; univariate analysis; Academic Medical Centers; Aged; Aged, 80 and over; Cohort Studies; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kaplan-Meiers Estimate; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Taiwan; Treatment Outcome |
顯示於: | 醫學系 |
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