https://scholars.lib.ntu.edu.tw/handle/123456789/532364
標題: | Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis | 作者: | CHIH-KANG CHIANG Hsu S.-P. Pai M.-F. Peng Y.-S. Ho T.-I. Liu S.-H. KUAN-YU HUNG TUN-JUN TSAI Hsieh B.-S. |
公開日期: | 2005 | 卷: | 23 | 期: | 2 | 起(迄)頁: | 144-148 | 來源出版物: | Blood Purification | 摘要: | Background/Aims: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. Results: Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and Kt/Vurea were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. Conclusion: Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α. Copyright ? 2005 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-16344371004&doi=10.1159%2f000083620&partnerID=40&md5=ecf413a0bb99ac5de3df8d4ad49a519a https://scholars.lib.ntu.edu.tw/handle/123456789/532364 |
ISSN: | 0253-5068 | DOI: | 10.1159/000083620 | SDG/關鍵字: | creatinine; interleukin 16; interleukin 18; nitrogen; tumor necrosis factor alpha; urea; adult; article; cell differentiation; comparative study; continuous ambulatory peritoneal dialysis; controlled study; creatinine clearance; dialysis; enzyme linked immunosorbent assay; female; human; kidney failure; major clinical study; male; priority journal; protein blood level; Th1 cell; urea blood level; urea nitrogen blood level; uremia; Biological Markers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-18; Interleukin-6; Kidney Failure, Chronic; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Tumor Necrosis Factor-alpha; Uremia |
顯示於: | 醫學系 |
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