https://scholars.lib.ntu.edu.tw/handle/123456789/532422
標題: | GB virus C/hepatitis G virus infection in patients on continuous ambulatory peritoneal dialysis | 作者: | Huang C.-H. JIA-HORNG KAO Kuo Y.-M. TUN-JUN TSAI KUAN-YU HUNG DING-SHINN CHEN |
公開日期: | 1998 | 卷: | 13 | 期: | 11 | 起(迄)頁: | 2914-2919 | 來源出版物: | Nephrology Dialysis Transplantation | 摘要: | Background. GB virus C or hepatitis G virus (GBV-C/HGV) can be transmitted parenterally, very likely sharing common routes of transmission with hepatitis C virus (HCV). Patients on maintenance haemodialysis have been shown to be at increased risk of the novel GBV-C/HGV infection. Whether continuous ambulatory peritoneal dialysis (CAPD) can reduce the risk of GBV-C/HGV infection as demonstrated for HCV remains unknown. Methods. Serum GBV-C/HGV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) with nested primers derived from the 5'-untranslated region (5' UTR) of the viral genome. We investigated the prevalence of GBV-C/HGV viraemia in 60 patients on CAPD and the possible routes of transmission. One hundred healthy adults were selected as controls. Results. The prevalence of GBV-C/HGV viraemia in CAPD patients was 23.3%, compared with 1% of healthy adults (P < 0.05). Compared with patients without hepatitis B virus (HBV), HCV or GBV-C/HGV infection (n = 39), those with GBV-C/HGV infection alone (n = 11) have received more blood transfusions (mean 18.9 units vs 6.8 units, P < 0.05). There were no significant differences between the viraemic and non-viraemic groups with respect to age, gender, duration of CAPD, duration of previous haemodialysis, previous history of surgery and co-infection with HBV or HCV. Three of the 11 (27.3%) patients with GBV-C/HGV infection alone had elevated serum alanine aminotransferase (ALT) level, and the frequency was significantly higher than that of patients negative for the viraemia (0%, P < 0.05). In addition, the mean serum ALT level was also higher in the group with GBV-C/HGV infection compared with those without HBV, HCV and GBV-C/HGV infections (22.3 ± 16.9 U/l vs 14.0 ± 6.8 U/l, P < 0.01). Conclusions. Patients on CAPD are at increased risk of GBV-C/HGV infection, and the risk parallels the number of previously transfused units of blood. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031757457&doi=10.1093%2fndt%2f13.11.2914&partnerID=40&md5=1067be802acb03b3a1e11c1a402c4aaa https://scholars.lib.ntu.edu.tw/handle/123456789/532422 |
ISSN: | 0931-0509 | DOI: | 10.1093/ndt/13.11.2914 | SDG/關鍵字: | alanine aminotransferase; virus RNA; aged; alanine aminotransferase blood level; article; blood transfusion; continuous ambulatory peritoneal dialysis; controlled study; female; hepatitis; Hepatitis G virus; high risk patient; human; immunoassay; major clinical study; male; priority journal; reverse transcription polymerase chain reaction; school child; viremia; virus transmission; Adolescent; Adult; Aged; Alanine Transaminase; Blood Transfusion; Female; Flaviviridae; Hepatitis C; Hepatitis, Viral, Human; Humans; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Prevalence |
顯示於: | 醫學系 |
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