https://scholars.lib.ntu.edu.tw/handle/123456789/532746
標題: | Impacts of a mass vaccination campaign against pandemic H1N1 2009 influenza in Taiwan: A time-series regression analysis | 作者: | UN-IN WU JANN-TAY WANG SHAN-CHWEN CHANG YU-CHUNG CHUANG Lin W.-R. Lu M.-C. Lu P.-L. Hu F.-C. Chuang J.-H. YEE-CHUN CHEN SZU-MIN HSIEH Chien S.-F. Chang H.-H. Chang Y.-Y. Lin H.-C. Hong M.-C. |
公開日期: | 2014 | 出版社: | Elsevier | 卷: | 23 | 起(迄)頁: | 82-89 | 來源出版物: | International Journal of Infectious Diseases | 摘要: | Objectives: A multicenter, hospital-wide, clinical and epidemiological study was conducted to assess the effectiveness of the mass influenza vaccination program during the 2009 H1N1 influenza pandemic, and the impact of the prioritization strategy among people at different levels of risk. Methods and results: Among the 34359 medically attended patients who displayed an influenza-like illness and had a rapid influenza diagnostic test (RIDT) at one of the three participating hospitals, 21.0% tested positive for influenza A. The highest daily number of RIDT-positive cases in each hospital ranged from 33 to 56. A well-fitted multiple linear regression time-series model (R2=0.89) showed that the establishment of special community flu clinics averted an average of nine cases daily (p=0.005), and an increment of 10% in daily mean level of population immunity against pH1N1 through vaccination prevented five cases daily (p<0.001). Moreover, the regression model predicted five-fold or more RIDT-positive cases if the mass influenza vaccination program had not been implemented, and 39.1% more RIDT-positive cases if older adults had been prioritized for vaccination above school-aged children. Conclusions: Mass influenza vaccination was an effective control measure, and school-aged children should be assigned a higher priority for vaccination than older adults during an influenza pandemic. ? 2014 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899865674&doi=10.1016%2fj.ijid.2014.02.016&partnerID=40&md5=f0e83b051286341b842d3af8d03fb4b4 https://scholars.lib.ntu.edu.tw/handle/123456789/532746 |
ISSN: | 1201-9712 | DOI: | 10.1016/j.ijid.2014.02.016 | SDG/關鍵字: | influenza vaccine; 2009 H1N1 influenza; adolescent; adult; article; child; clinical effectiveness; diagnostic test; disease surveillance; female; hospital patient; human; immunogenicity; infant; infection control; infection prevention; infection risk; influenza vaccination; major clinical study; mass immunization; multicenter study; outpatient; pharmaceutical care; potential difference; surgical mask; Taiwan; tertiary care center; time series analysis; aged; clinical trial; epidemiology; Influenza virus A H1N1; Influenza, Human; mass immunization; middle aged; pandemic; preschool child; procedures; statistical model; young adult; Adolescent; Adult; Aged; Child; Child, Preschool; Epidemiologic Studies; Humans; Infant; Influenza A Virus, H1N1 Subtype; Influenza, Human; Linear Models; Mass Vaccination; Middle Aged; Pandemics; Taiwan; Young Adult |
顯示於: | 醫學系 |
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