https://scholars.lib.ntu.edu.tw/handle/123456789/533362
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEN-HUI CHEN | en_US |
dc.contributor.author | Huang L.-H. | en_US |
dc.contributor.author | Chen T.-M. | en_US |
dc.creator | Yen-Hui Chen;Huang L.-H.;Chen T.-M. | - |
dc.date.accessioned | 2020-12-28T02:40:20Z | - |
dc.date.available | 2020-12-28T02:40:20Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0006291X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030601195&doi=10.1006%2fbbrc.1996.1080&partnerID=40&md5=c7fe0c5054d079be2dee01e8914d2f79 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/533362 | - |
dc.description.abstract | We have studied effects of a series of progestins and estrogens on regulation of human papillomavirus (IBV) types 16 and 18 gene expression via long control region (LCR), using a transient expression assay which represented the episomal state of HPVs in precancerous lesions. Results showed that HPV gene expression induced by these steroid analogs were diverse. Gene expression via HPV16-LCR was upregulated 2-3 fold under treatment with 10-7 M estriol, 17β-estradiol, and several progestins including pregnenolone, 17α-hydroxy-progesterone, norethynodrel and cyproterone acetate. However, transcription via HPV18-LCR was not or weakly stimulated by these analogs. Our results can divide these analogs into HPV-enhancing and HPV-nonenhancing groups and accordingly impact the relative risk of individual oral contraceptive ingredient in cervical carcinogenesis. | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 17 hydroxypregnenolone; cyproterone acetate; estradiol; estriol; estrogen; gestagen; noretynodrel; oral contraceptive agent; pregnenolone; article; controlled study; DNA transcription; episome; gene expression regulation; human; human cell; nonhuman; precancer; priority journal; risk; uterine cervix cancer; virus genome; Wart virus | - |
dc.title | Differential effects of progestins and estrogens on long control regions of human papillomavirus types 16 and 18 | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1006/bbrc.1996.1080 | - |
dc.identifier.pmid | 8713103 | - |
dc.identifier.scopus | 2-s2.0-0030601195 | - |
dc.relation.pages | 651-659 | - |
dc.relation.journalvolume | 224 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.orcid | 0000-0003-2966-1622 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 臨床藥學研究所 |
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