https://scholars.lib.ntu.edu.tw/handle/123456789/533958
標題: | Immediate results and long-term cardiovascular outcomes of endovascular therapy in octogenarians and nonoctogenarians with peripheral arterial diseases | 作者: | Huang H.-L. JYH-MING JIMMY JUANG Chou H.-H. Hsieh C.-A. Jang S.-J. Cheng S.-T. Ko Y.-L. |
公開日期: | 2016 | 出版社: | Dove Medical Press Ltd. | 卷: | 11 | 起(迄)頁: | 535-543 | 來源出版物: | Clinical Interventions in Aging | 摘要: | Purpose: To investigate the clinical outcomes of endovascular therapy (EVT) in octogenarians and nonoctogenarians with peripheral arterial disease. Methods: A retrospective analysis of 511 patients (654 affected legs) who underwent EVT between July 2005 and December 2013 was conducted in a prospectively maintained database. Immediate results and long-term vascular outcomes were analyzed and compared between octogenarians and nonoctogenarians. Results: Octogenarians were more likely to be female and have atrial fibrillation (AF), whereas nonoctogenarians had higher rates of obesity, claudication, and medical comorbidities. There were no differences in the rates of EVT success, 30-day major adverse vascular events, and 6-month functional improvement between groups. Over the 10-year follow-up period, the rates of 3-year limb salvage, sustained clinical success, freedom from major cerebrovascular and cardiovascular events, and composite vascular events were similar between groups, but the survival rate was better in nonoctogenarians than in octogenarians (73% vs 63%, respectively, P=0.004). In Cox regression analysis, dependence on dialysis and AF were significant predictors of death (odds ratio [OR] 4.44 in dialyzed and 2.83 in AF patients), major cerebrovascular and cardiovascular events (OR 3.49 and 2.45), and composite vascular events (OR 3.14 and 2.25). Conclusion: EVT in octogenarians was feasible, without an increased risk of periprocedural complications. The rates of limb salvage, sustained clinical success, and long-term vascular events were comparable between groups. Dialysis dependence and AF are independent predictors for poor prognosis in patients with peripheral arterial disease. However, these observations require further confirmation in larger scale studies. ? 2016 Huang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84967020002&doi=10.2147%2fCIA.S106119&partnerID=40&md5=7258546d28bf4146b627ae1db4b01dfe https://scholars.lib.ntu.edu.tw/handle/123456789/533958 |
ISSN: | 1176-9092 | DOI: | 10.2147/CIA.S106119 | SDG/關鍵字: | aged; Article; atrial fibrillation; cardiovascular disease; cardiovascular mortality; cerebrovascular accident; cerebrovascular disease; claudication; clinical effectiveness; comorbidity; controlled study; dialysis; endovascular surgery; female; follow up; hospital mortality; hospitalization; human; in hospital mortality; leg ischemia; limb salvage; major clinical study; male; obesity; overall survival; peripheral occlusive artery disease; prospective study; register; retrospective study; safety; sepsis; survival rate; very elderly; age; cardiovascular disease; mortality; odds ratio; peripheral occlusive artery disease; regression analysis; statistics and numerical data; treatment outcome; Age Factors; Aged, 80 and over; Cardiovascular Diseases; Comorbidity; Female; Humans; Limb Salvage; Male; Odds Ratio; Peripheral Arterial Disease; Regression Analysis; Retrospective Studies; Survival Rate; Treatment Outcome |
顯示於: | 醫學系 |
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