https://scholars.lib.ntu.edu.tw/handle/123456789/534214
標題: | Cytomegalovirus-associated immune thrombocytopenic purpura after liver transplantation | 作者: | Wei S.-H. MING-CHIH HO YEN-HSUAN NI DONG-TSAMN LIN PO-HUANG LEE |
公開日期: | 2007 | 出版社: | Scientific Communications International Ltd | 卷: | 106 | 期: | 4 | 起(迄)頁: | 327-329 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Immune thrombocytopenic purpura (ITP) is a rare complication after liver transplantation. Infection with cytomegalovirus (CMV) is a frequent complication of organ transplantation and may induce autoimmune diseases, such as ITP. We report a case of ITP after primary CMV infection in a 3-year-old boy recipient of living-related orthotopic liver transplantation (OLT). The ITP developed 2 years after OLT in this patient who had received tacrolimus as an immunosuppressive agent, with nadir platelet counts of 5000/mm3 in 2 weeks. The patient was treated with two courses of intravenous gamma globulin (1 g/kg/day for 2 days) and subsequent oral prednisolone (1.3 mg/kg/day for 2 weeks). He recovered from thrombocytopenia 4 weeks later. An inadequate immunosuppression, as evident by the low serum tacrolimus level (5.8 ng/ mL before the episode of ITP) in this patient, may allow the development of ITP after CMV infection. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34248651552&doi=10.1016%2fS0929-6646%2809%2960261-8&partnerID=40&md5=d3138788f6ba36ffd4ddbc55b36324cd https://scholars.lib.ntu.edu.tw/handle/123456789/534214 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60261-8 | SDG/關鍵字: | immunoglobulin; prednisolone; steroid; tacrolimus; antibody blood level; article; blood examination; case report; child; cytomegalovirus infection; drug blood level; graft rejection; human; liver transplantation; living donor; male; orthotopic transplantation; repeated drug dose; serology; thrombocyte count; thrombocytopenia; thrombocytopenic purpura; treatment duration; treatment outcome |
顯示於: | 醫學系 |
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