https://scholars.lib.ntu.edu.tw/handle/123456789/535203
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YU-CHUNG CHUANG | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | Lauderdale T.-L. | en_US |
dc.contributor.author | Li S.-Y. | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | YEE-CHUN CHEN | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.date.accessioned | 2020-12-29T03:48:03Z | - |
dc.date.available | 2020-12-29T03:48:03Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904498158&doi=10.1016%2fj.jmii.2013.03.008&partnerID=40&md5=4d07bce2a661bb5c990fea32a5b2f25a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535203 | - |
dc.description.abstract | Background: Emerging carbapenem resistance among Acinetobacter baumannii clinical isolates is a worldwide problem. Infections caused by A. baumannii are increasing and demonstrate high mortality rates. This study aimed to establish a nationwide surveillance of antimicrobial susceptibility, carbapenemase genes, and clonal relationships of A. baumannii clinical isolates in Taiwan. Methods: Clinical isolates of Acinetobacter calcoaceticus-A. baumannii (ACB) complex collected by the Taiwan Surveillance of Antimicrobial Resistance-V program between July 2006 and September 2006 were used in this study. Genospecies identification was verified by 16S-23S rRNA intergenic-spacer sequences. Carbapenemase genes were detected by polymerase chain reaction. Pulsed-field gel electrophoresis and multilocus sequence typing (MLST) was applied for identification of clonal relationships. Results: Among the 151 ACB-complex isolates collected, 134 (88.7%) were A. baumannii, 12 (8.0%) were A. pittii, and five (3.3%) were A. nosocomialis. A. baumannii isolates showed higher resistance rates to ciprofloxacin, amikacin, and ampicillin/sulbactam than A. pittii or A. nosocomialis (all p<0.001). The most commonly detected carbapenemase genes were blaOxA-51 (n=135), followed by blaOxA-24 (n=4), blaOxA-23 (n=2), and blaOxA-58 (n=1). Three major A. baumannii clones were found throughout Taiwan, and showed significantly higher resistance rates to ciprofloxacin, amikacin, and ampicillin/sulbactam than the other A. baumannii isolates (100% vs. 68.7%, p<0.001; 98.4% vs. 61.5%, p<0.001; and 66.7% vs. 39.8%, p=0.004; respectively). MLST showed that these major clones were sequence type 2 and belonged to international clonal complex 2. Conclusion: Our results demonstrate clonal spreading of A. baumannii in Taiwan hospitals and that these clones were more resistant to many antimicrobial agents. Efforts to prevent and control A. baumannii colonization/infections and prudent use of antibiotics to reduce antimicrobial selective pressure should be emphasized. ? 2013. | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amikacin; antibiotic agent; carbapenem; carbapenemase; ciprofloxacin; colistin; imipenem; RNA 16S; RNA 23S; sultamicillin; tigecycline; antiinfective agent; carbapenem derivative; Acinetobacter baumannii; Acinetobacter calcoaceticus; Acinetobacter nosocomialis; Acinetobacter pittii; antibiotic resistance; antibiotic sensitivity; article; bacterium isolate; minimum inhibitory concentration; molecular epidemiology; multilocus sequence typing; nonhuman; polymerase chain reaction; pulsed field gel electrophoresis; Taiwan; Acinetobacter baumannii; Acinetobacter Infections; cluster analysis; drug effects; genetics; genotype; health survey; human; isolation and purification; microbial sensitivity test; microbiology; Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactam Resistance; Carbapenems; Cluster Analysis; Electrophoresis, Gel, Pulsed-Field; Genotype; Humans; Microbial Sensitivity Tests; Multilocus Sequence Typing; Public Health Surveillance; Taiwan | - |
dc.title | Molecular epidemiology, antimicrobial susceptibility and carbapenemase resistance determinants among Acinetobacter baumannii clinical isolates in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2013.03.008 | - |
dc.identifier.pmid | 23726465 | - |
dc.relation.pages | 324-332 | - |
dc.relation.journalvolume | 47 | - |
dc.relation.journalissue | 4 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0003-3094-8276 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0002-1816-9010 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。