|Title:||Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in HIV-infected individuals in Taiwan||Authors:||SUI-YUAN CHANG
|Issue Date:||2009||Journal Volume:||48||Journal Issue:||6||Start page/Pages:||832-835||Source:||Clinical Infectious Diseases||Abstract:||
We investigated the relationship between hypertriglyceridemia and the single-nudeotide polymorphisms(SNPs) on APOA5 in human immunodeficiency virus(HlV)-infected patients receiving highly active antiretroviral therapy(HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP117 SNP2G/SNP3C/C.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia(triglyceride level, >500 mg/dL).?2009 by the Infectious Diseases Society of America. All rights reserved.
|ISSN:||1058-4838||DOI:||10.1086/597099||SDG/Keyword:||antilipemic agent; atazanavir; efavirenz; indinavir; indinavir plus ritonavir; lopinavir plus ritonavir; nelfinavir; nevirapine; proteinase inhibitor; ritonavir; ritonavir plus saquinavir; RNA directed DNA polymerase inhibitor; saquinavir; stavudine; triacylglycerol; APOA5 protein, human; apolipoprotein A; adult; aged; APOA5 gene; article; controlled study; female; gene; genetic association; genetic variability; haplotype; highly active antiretroviral therapy; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; major clinical study; male; priority journal; side effect; single nucleotide polymorphism; Taiwan; triacylglycerol blood level; genetics; highly active antiretroviral therapy; Human immunodeficiency virus infection; hypertriglyceridemia; middle aged; point mutation; Adult; Aged; Aged, 80 and over; Antiretroviral Therapy, Highly Active; Apolipoproteins A; Female; Haplotypes; HIV Infections; HIV Protease Inhibitors; Humans; Hypertriglyceridemia; Male; Middle Aged; Point Mutation; Polymorphism, Single Nucleotide; Taiwan; Young Adult
|Appears in Collections:||醫學系|
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