https://scholars.lib.ntu.edu.tw/handle/123456789/535259| Title: | Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in HIV-infected individuals in Taiwan | Authors: | SUI-YUAN CHANG Ko W.-S. JAU-TSUEN KAO Chang L.-Y. HSIN-YUN SUN Chen M.-Y. SZU-MIN HSIEH WANG-HUEI SHENG Chang S.-F. Liu W.-C. Wu C.-H. Hsu H.-J. CHUAN-LIANG KAO Lee C.-N. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
Issue Date: | 2009 | Journal Volume: | 48 | Journal Issue: | 6 | Start page/Pages: | 832-835 | Source: | Clinical Infectious Diseases | Abstract: | We investigated the relationship between hypertriglyceridemia and the single-nudeotide polymorphisms(SNPs) on APOA5 in human immunodeficiency virus(HlV)-infected patients receiving highly active antiretroviral therapy(HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP117 SNP2G/SNP3C/C.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia(triglyceride level, >500 mg/dL).?2009 by the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-62449147005&doi=10.1086%2f597099&partnerID=40&md5=dffaaf8fe97cdf4d4790fddd26314232 https://scholars.lib.ntu.edu.tw/handle/123456789/535259 |
ISSN: | 1058-4838 | DOI: | 10.1086/597099 | SDG/Keyword: | antilipemic agent; atazanavir; efavirenz; indinavir; indinavir plus ritonavir; lopinavir plus ritonavir; nelfinavir; nevirapine; proteinase inhibitor; ritonavir; ritonavir plus saquinavir; RNA directed DNA polymerase inhibitor; saquinavir; stavudine; triacylglycerol; APOA5 protein, human; apolipoprotein A; adult; aged; APOA5 gene; article; controlled study; female; gene; genetic association; genetic variability; haplotype; highly active antiretroviral therapy; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; major clinical study; male; priority journal; side effect; single nucleotide polymorphism; Taiwan; triacylglycerol blood level; genetics; highly active antiretroviral therapy; Human immunodeficiency virus infection; hypertriglyceridemia; middle aged; point mutation; Adult; Aged; Aged, 80 and over; Antiretroviral Therapy, Highly Active; Apolipoproteins A; Female; Haplotypes; HIV Infections; HIV Protease Inhibitors; Humans; Hypertriglyceridemia; Male; Middle Aged; Point Mutation; Polymorphism, Single Nucleotide; Taiwan; Young Adult [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
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