https://scholars.lib.ntu.edu.tw/handle/123456789/535260
Title: | Antimicrobial and immunomodulatory attributes of statins: Relevance in solid-organ transplant recipients | Authors: | HSIN-YUN SUN Singh N. |
Issue Date: | 2009 | Journal Volume: | 48 | Journal Issue: | 6 | Start page/Pages: | 745-755 | Source: | Clinical Infectious Diseases | Abstract: | Statins are increasingly being used to treat solid-organ transplant recipients for posttransplantation metabolic complications. In addition to improving dyslipidemia, statins also have manifold non-lipid-lowering effects. With regard to sepsis or infection, these agents modify the inflammatory cascades by pleiotropic actions at multiple levels and exhibit activities against opportunistic bacteria, fungi, and viruses that can cause serious infections in solid-organ transplant recipients. They also have synergistic interactions with antimicrobial agents. Statins with antimicrobial and immunomodulatory attributes might improve morbidity and mortality attributable to sepsis or infection in solid-organ transplant recipients. ? 2009 by the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-62449100121&doi=10.1086%2f597039&partnerID=40&md5=176fd420d7b6e5ab1013b6c9cda62020 https://scholars.lib.ntu.edu.tw/handle/123456789/535260 |
ISSN: | 1058-4838 | DOI: | 10.1086/597039 | SDG/Keyword: | alpha interferon; amphotericin B; antifungal agent; antiinfective agent; apoptosis inducing factor; atorvastatin; C reactive protein; caspofungin; caveolin 1; cerivastatin; compactin; ergosterol; fluconazole; fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; immunoglobulin enhancer binding protein; intercellular adhesion molecule 1; interleukin 1beta converting enzyme; itraconazole; latent membrane protein 1; mevalonic acid; mevinolin; mitogen activated protein kinase; pitavastatin; pravastatin; rosuvastatin; signal peptide; simvastatin; voriconazole; antiinfective agent; cell cycle protein; immunologic factor; STN protein, human; acute coronary syndrome; antifungal activity; antigen expression; antimicrobial activity; article; aspergillosis; atherosclerotic cardiovascular disease; bacteremia; bacterial growth; BK virus; Candida; candidiasis; carcinogenesis; caveola; cell interaction; cerebrovascular accident; cholesterol synthesis; chronic obstructive lung disease; community acquired pneumonia; coronary artery obstruction; cytokine production; cytokine release; Cytomegalovirus; cytomegalovirus infection; diabetes mellitus; DNA synthesis; dose response; drug blood level; drug mechanism; drug potentiation; drug protein binding; dyslipidemia; Epstein Barr virus; graft infection; graft recipient; graft rejection; growth inhibition; helper cell; hemodialysis; hepatitis C; hospitalization; host resistance; human; Human immunodeficiency virus infection; immune response; immunomodulation; infection complication; infection risk; influenza; internalization; kidney disease; kidney proximal tubule; lipid raft; lymphoproliferative disease; metabolic disorder; methicillin resistant Staphylococcus aureus infection; minimum inhibitory concentration; morbidity; mortality; mucormycosis; Mycobacterium tuberculosis; nonhuman; organ transplantation; Penicillium chrysogenum; pleiotropy; pneumonia; Polyoma virus; postoperative complication; postoperative infection; prenylation; priority journal; protein interaction; protein prenylation; revascularization; risk reduction; sepsis; sporangiospore; staphylococcal bacteremia; Th1 cell; treatment response; tuberculosis; virulence; virus entry; virus inhibition; virus particle; virus replication; Zygomycetes; bacterium; drug effect; fungus; review; sepsis; transplantation; virus; Anti-Infective Agents; Bacteria; Cell Cycle Proteins; Fungi; Humans; Immunologic Factors; Sepsis; Transplantation; Viruses |
Appears in Collections: | 醫學系 |
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