https://scholars.lib.ntu.edu.tw/handle/123456789/535396
標題: | The usefulness of the Platelia Candida antigen in a patient with acute lymphocytic leukemia and chronic disseminated candidiasis | 作者: | HSIN-YUN SUN Chiu Y.-S. JIH-LUH TANG Wang J.-L. SHAN-CHWEN CHANG YEE-CHUN CHEN |
公開日期: | 2006 | 卷: | 44 | 期: | 7 | 起(迄)頁: | 647-650 | 來源出版物: | Medical Mycology | 摘要: | We report a protracted course of disseminated candidiasis due to Candida tropicalis in a 17-year-old man with acute lymphocytic leukemia. Despite adequate antifungal therapy (amphotericin B), C. tropicalis was recovered from biopsy specimens 25 days (skin) and 109 days (kidney) after the first positive blood cultures. While blood cultures became negative for C. tropicalis 11 days after the initiation of treatment, mannanemia persisted and became negative only after 130 days of antifungal therapy. Thus, antigen assays provided indicators of antifungal response. Differential diagnosis was difficult for this patient with the observation of persistent lesions in image studies. With positive results of antigen assays, an invasive procedure might be avoided and preemptive antifungal treatment could be initiated in a timely manner. Anti-mannan antibody remained undetectable up to 164 days after first positive blood culture despite the patient's recovery from neutropenia and recruitment of neutrophils in the tissue (skin). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750483591&doi=10.1080%2f13693780600735445&partnerID=40&md5=555bc3dd661ee60787430d5e72a3faf8 https://scholars.lib.ntu.edu.tw/handle/123456789/535396 |
ISSN: | 1369-3786 | DOI: | 10.1080/13693780600735445 | SDG/關鍵字: | amphotericin B; antibody; antifungal agent; asparaginase; Candida antigen; cefepime; ceftazidime; cefuroxime; cyclophosphamide; doxorubicin; fluconazole; folinic acid; ifosfamide; mannan; mesna; methotrexate; methylprednisolone sodium succinate; prednisolone; prednisone; vincristine; acute lymphocytic leukemia; adolescent; article; blood culture; Candida tropicalis; candidiasis; case report; chronic disease; clinical feature; death; diagnostic value; differential diagnosis; drug fever; Escherichia coli; febrile neutropenia; fever; follow up; hospital admission; human; image analysis; immunoassay; interstitial nephritis; invasive procedure; kidney biopsy; liver dysfunction; liver toxicity; male; neutrophil count; pyuria; skin biopsy; skin culture; treatment outcome; Adolescent; Antibodies, Fungal; Antigens, Fungal; Candida tropicalis; Candidiasis; Humans; Leukemia, Lymphocytic; Male; Mannans; Neutropenia; Candida; Candida tropicalis |
顯示於: | 醫學系 |
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