https://scholars.lib.ntu.edu.tw/handle/123456789/535448
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | Chen M.-Y. | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Szu-Min Hsieh;Hung C.-C.;Chen M.-Y.;Sheng W.-H.;Chang S.-C. | - |
dc.date.accessioned | 2020-12-29T06:37:16Z | - |
dc.date.available | 2020-12-29T06:37:16Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0269-9370 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033007830&doi=10.1097%2f00002030-199905280-00009&partnerID=40&md5=dffa5ad6b6982380659123ca442c63f2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535448 | - |
dc.description.abstract | Objective: To examine whether the serial measurement of plasma cytokine levels can assist in the early recognition of AIDS/tuberculosis patients with poor response to anti-tuberculosis treatment. Design: Longitudinal, prospective cohort study. Setting: A university hospital, the largest centre for HIV/AIDS patients in Taiwan. Methods: Between January 1997 and September 1998, 25 consecutive patients with advanced HIV infection and suspected tuberculosis were enrolled in the study. Plasma samples were obtained on day 1 (baseline), 3, 7 and 14 of anti-tuberculosis treatment and the levels of tumour necrosis factor-α (TNF-α) were measured. Patients were classified as either responders or non-responders according to the results of assessment of symptoms and follow-up cultures during the sixth and eighth week of anti-tuberculosis treatment. Thirty consecutive HIV-negative tuberculosis patients were also enrolled in the study. Results: The data of a total of 16 AIDS patients (median CD4 cell count 16 x 106/l; 12 responders and four non-responders) and 21 HIV-negative patients (16 responders and five non-responders), whose tuberculosis was culture-proven, were included for analysis. In responders, TNF-α levels declined remarkably within the first week of anti-tuberculosis treatment; however, the decline of TNF-α levels in non-responders was significantly less [the median ratio of TNF-α level on day 7 to that at baseline was 0.32 versus 0.85 (P < 0.001) in AIDS patients; 0.34 versus 0.80 (P = 0.001) in HIV-negative patients). The lack of a ? 50% reduction in pre-treatment TNF-α levels during the first week of treatment was strongly associated with a poor response to anti-tuberculosis treatment (P = 0.001 in AIDS patients; P < 0.001 in HIV-negative patients). Conclusion: Serial measurement of plasma TNF-α levels may help to assess the response to anti-tuberculosis treatment in AIDS patients, in spite of very low CD4 cell counts. Failure of TNF-α levels to decline by ? 50% of pre-treatment levels in the first week of treatment may be an early surrogate marker of a poor response. | - |
dc.relation.ispartof | AIDS | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cd4 antigen; cytokine; tuberculostatic agent; tumor necrosis factor alpha; acquired immune deficiency syndrome; adult; article; bacterium culture; cohort analysis; early diagnosis; female; follow up; human; human cell; human immunodeficiency virus infection; leukocyte count; major clinical study; male; priority journal; prospective study; tuberculosis; Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Cohort Studies; Cytokines; Female; Humans; Interleukin-10; Longitudinal Studies; Male; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Prospective Studies; Treatment Outcome; Tuberculosis; Tumor Necrosis Factor-alpha | - |
dc.title | Dynamics of plasma cytokine levels in patients with advanced HIV infection and active tuberculosis: Implications for early recognition of patients with poor response to anti-tuberculosis treatment | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1097/00002030-199905280-00009 | - |
dc.identifier.pmid | 10371174 | - |
dc.relation.pages | 935-941 | - |
dc.relation.journalvolume | 13 | - |
dc.relation.journalissue | 8 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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