https://scholars.lib.ntu.edu.tw/handle/123456789/535486
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | Hsiao C.-F. | en_US |
dc.contributor.author | Wang J.-L. | en_US |
dc.contributor.author | Chen M.-Y. | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Hung C.-C.;Hsiao C.-F.;Wang J.-L.;Chen M.-Y.;Szu-Min Hsieh;Sheng W.-H.;Chang S.-C. | - |
dc.date.accessioned | 2020-12-29T06:37:27Z | - |
dc.date.available | 2020-12-29T06:37:27Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0956-4624 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27344431604&doi=10.1258%2f095646205774357271&partnerID=40&md5=fc8f7a5d4a931a87604553795ad550a5 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535486 | - |
dc.description.abstract | Between June 1994 and May 2003, 93 of 716 (13.0%) HIV-infected patients with a median baseline cell differentiation CD4+ count of 61 × 10 6 cells/L (range, 1-1206 × 106 cells/L) developed 103 episodes of herpes zoster [HZ], with an incidence of 5.67 per 100 person-years (PY). The incidence of HZ in the pre-highly active antiretroviral therapy (HAART) era (17.21 per 100 PY) was significantly higher than that in the post-HAARTera (5.05 per 100 PY) (P < 0.0001). In the first six months of enrolment, the incidence of HZ was significantly higher than that between six and 12 months both in the pre-HAART (27.65 per 100 PY versus 8.43 per 100 PY, P = 0.02) and post-HAART era (17.79 per 100 PY versus 3.39 per 100 PY, P < 0.0001). In multivariate analyses, only baseline CD4+ count remained a significant risk factor associated with HZ. HZ did not increase mortality rate either in the pre-HAART or post-HAART era, although the risk for HIV progression was significantly higher in patients with HZ (adjusted odds ratio [OR], 1.747, 95% confidence interval, 1.037-2.943). We conclude that the incidence of HZ was highest in the first six months of enrolment in patients at late stage of HIV infection, which did not increase with the introduction of HAART. Baseline CD4+ lymphocyte count was the most significant risk factor associated with development of HZ. HZ was associated with increased risk for HIV progression, but not mortality. | - |
dc.relation.ispartof | International Journal of STD and AIDS | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antivirus agent; CD4 antigen; RNA directed DNA polymerase inhibitor; adult; aged; article; cell differentiation; clinical trial; controlled clinical trial; controlled study; disease association; disease course; female; herpes zoster; high risk patient; highly active antiretroviral therapy; human; human cell; incidence; infection risk; lymphocyte; lymphocyte differentiation; major clinical study; male; mortality; multivariate analysis; priority journal; prospective study; risk assessment; risk factor; statistical significance; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Herpes Zoster; Herpesvirus 3, Human; HIV Infections; HIV-1; Humans; Prevalence; Prospective Studies | - |
dc.title | Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: A prospective observational study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1258/095646205774357271 | - |
dc.identifier.pmid | 16212714 | - |
dc.relation.pages | 673-676 | - |
dc.relation.journalvolume | 16 | - |
dc.relation.journalissue | 10 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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