https://scholars.lib.ntu.edu.tw/handle/123456789/535569
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kao T.M. | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | HSIANG-CHI KUNG | en_US |
dc.contributor.author | Lee Y.C. | en_US |
dc.contributor.author | KUO-CHIN HUANG | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.contributor.author | Chang F.Y. | en_US |
dc.contributor.author | Wang N.C. | en_US |
dc.contributor.author | Liu Y.C. | en_US |
dc.contributor.author | Lee W.S. | en_US |
dc.contributor.author | Liu H.E. | en_US |
dc.contributor.author | Chen C.I. | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.date.accessioned | 2020-12-29T06:37:49Z | - |
dc.date.available | 2020-12-29T06:37:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955661281&doi=10.1016%2fj.vaccine.2010.07.026&partnerID=40&md5=028b9e3692649171c9a04bbc6a88a0a6 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535569 | - |
dc.description.abstract | We conducted a multi-center, randomized and laboratory-blinded clinical trial with subgroup analyses, involving adults aged greater than 60 years old (range 61-86 years old), to investigate the immunogenicity and the potential factors affecting the immune response of a monovalent, unadjuvanted, inactivated, split-virus vaccine. A total of 107 subjects were randomized to receive 15 and 30μg of hemagglutinin antigen in a 1:1 ratio. The immunogenicity was detected through hemagglutination inhibition (HAI) test of serum obtained before and 3 weeks after vaccination. By 3 weeks after vaccination, HAI titer ?1:40 was observed in 75.5% and 81.1% of participants receiving 15 and 30μg of hemagglutinin antigen, respectively. Positive seroconversion was observed in 71.7% and 81.1% of recipients of the 15 and the 30μg, respectively. The GMTs increased by a factor of 10.7 and 17.4 in the groups of 15 and 30μg, respectively. This study indicated that one dose of 15μg hemagglutinin antigen without adjuvant induced protective immune response in the majority of elderly. Multivariate logistic regression analyses showed that gender, age and diabetes were statistically significant factors affecting the seroprotection rate (p=0.04, 0.01 and 0.01, respectively) and seroconversion rate (p=0.01, 0.01 and 0.01, respectively). ? 2010 Elsevier Ltd. | en_US |
dc.relation.ispartof | Vaccine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Influenza virus hemagglutinin; aged; antibody titer; article; body mass; clinical trial; comorbidity; controlled clinical trial; controlled study; diabetes mellitus; dose response; female; hemagglutination inhibition; human; immune response; immunogenicity; influenza A (H1N1); influenza vaccination; Influenza virus A H1N1; major clinical study; male; multicenter study; pandemic; priority journal; randomized controlled trial; seroconversion; Taiwan; Age Factors; Aged; Aged, 80 and over; Antibodies, Viral; Antibody Formation; Diabetes Mellitus; Female; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Logistic Models; Male; Middle Aged; Multivariate Analysis; Sex Factors; Single-Blind Method; Taiwan | - |
dc.title | Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.vaccine.2010.07.026 | - |
dc.identifier.pmid | 20659517 | - |
dc.relation.pages | 6159-6163 | en_US |
dc.relation.journalvolume | 28 | en_US |
dc.relation.journalissue | 38 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0002-6029-5520 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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