https://scholars.lib.ntu.edu.tw/handle/123456789/535798
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lu P.-L. | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.contributor.author | Chen W.-C. | en_US |
dc.contributor.author | Chen T.-C. | en_US |
dc.contributor.author | Hwang Y.-C. | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.date.accessioned | 2020-12-30T02:43:02Z | - |
dc.date.available | 2020-12-30T02:43:02Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0009-3157 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78349274628&doi=10.1159%2f000317752&partnerID=40&md5=9fe207c0d04a48126861c100e09486f8 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535798 | - |
dc.description.abstract | Background: Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported. Methods: Adult cases that received linezolid for bone and joint infections at 3 Taiwanese medical centers from 2002 to 2006 were analyzed. We investigated factors associated with treatment outcome and hematological adverse reactions. Results: Of the 51 cases that received linezolid for more than 3 days, 41 (80.4%) had a favorable outcome and 10 had a failed outcome. Based on univariate analysis, patients with renal/urinary tract diseases, gastrointestinal diseases, higher WBC counts, a higher alanine aminotransferase level, or a higher creatinine level prior to linezolid treatment were significantly associated with a failed outcome. Based on multivariate analysis, underlying gastrointestinal disease was the only significant factor for a failed outcome. Six patients stopped linezolid use due to adverse reactions. A failed outcome was significantly associated with anemia caused by linezolid. Conclusion: Linezolid is an effective salvage agent for bone and joint infections. However, adverse effects, especially hematological reactions, may cause drug discontinuation. Copyright ? 2010 S. Karger AG, Basel. | - |
dc.relation.ispartof | Chemotherapy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; cefazolin; ciprofloxacin; cotrimoxazole; creatinine; fusidic acid; gentamicin; linezolid; oxacillin; rifampicin; teicoplanin; vancomycin; adult; aged; anemia; antibiotic therapy; article; bone and joint infections; compassionate use; drug efficacy; drug hypersensitivity; drug treatment failure; drug withdrawal; female; gastrointestinal disease; human; kidney disease; leukocyte count; major clinical study; male; methicillin resistant Staphylococcus aureus infection; monotherapy; patient compliance; priority journal; thrombocytopenia; treatment outcome; treatment refusal; urinary tract disease; Acetamides; Adult; Anti-Infective Agents; Arthritis, Infectious; Compassionate Use Trials; Female; Humans; Male; Osteomyelitis; Oxazolidinones; Retrospective Studies; Staphylococcal Infections; Treatment Outcome | - |
dc.title | Compassionate use of linezolid for adult taiwanese patients with bone and joint infections | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000317752 | - |
dc.identifier.pmid | 21088393 | - |
dc.relation.pages | 429-435 | - |
dc.relation.journalvolume | 56 | - |
dc.relation.journalissue | 6 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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