https://scholars.lib.ntu.edu.tw/handle/123456789/535999
標題: | Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: A global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005 | 作者: | Pfaller M.A. Diekema D.J. Gibbs D.L. Newell V.A. Ng K.P. Colombo A. Finquelievich J. Barnes R. Wadula J. Finquelievich J. Tiraboschi N. Ellis D. Fameree D. van den Abeele A.-M. Senterre J.-M. Lopez Colombo A. Rennie R. Sanche S. Bijie H. Xu Y. Fu W. Zhong N.S. Rivas P. de Bedout C. Mendez M. Vega R. Mallatova N. Dobiasova S. Ayabaca J. Zurita J. Mallie M. Candolfi E. Fegeler W. Haase P.D.G. Rodloff A. Bar W. Czaika V. Petrikos G. Puskás E. Dóczi I. Mestyan G. Nikolova R. Banerjee U. Keller N. Tullio V. Carlo Schito G. D'Antonio D. Martino P. Kee Peng N.G. Alpuche C. Santos J. Morfin Ortero R. Zaidi M. Meis J.F. Lingaas E. Dzierzanowska D. Pawliszyn W. Luz Martins M. Albuquerque L. Rosado L. Velho R. Amorim J. Ilina V.N. Kretchikova O.I. Klyasova G.A. Rozanova S.M. Multykh I.G. Klimko N.N. Agapova E.D. Dmitrieva N.V. Al-Rasheed A.M. Shibl A. Trupl J. Helena H. Hoosen A. Wadula J. Janse van Rensburg M.N. Duse A. Lee K. Kim M.-N. del Palacio A. Sanchez-Sousa A. Bille J. Muhlethaler K. SHAN-CHWEN CHANG Wang J.-H. Gur D. Korten V. Paul J. Brown D. Kibbler C. Weightman N. Gould I.M. Rennison C. Barton R. Barnes R. Vazquez J. Larone D. Rinaldi M. Reyes H. Santiago A. |
公開日期: | 2008 | 卷: | 46 | 期: | 3 | 起(迄)頁: | 842-849 | 來源出版物: | Journal of Clinical Microbiology | 摘要: | We examined data from the ARTEMIS DISK Antifungal Surveillance Program to describe geographic and temporal trends in the isolation of Candida parapsilosis from clinical specimens and the in vitro susceptibilities of 9,371 isolates to fluconazole and voriconazole. We also report the in vitro susceptibility of bloodstream infection (BSI) isolates of C. parapsilosis to the echinocandins, anidulafungin, caspofungin, and micafungin. C. parapsilosis represented 6.6% of the 141,383 isolates of Candida collected from 2001 to 2005 and was most common among isolates from North America (14.3%) and Latin America (9.9%). High levels of susceptibility to both fluconazole (90.8 to 95.8%) and voriconazole (95.3 to 98.1%) were observed in all geographic regions with the exception of the Africa and Middle East region (79.3 and 85.8% susceptible to fluconazole and voriconazole, respectively). C. parapsilosis was most often isolated from blood and skin and/or soft tissue specimens and from patients hospitalized in the medical, surgical, intensive care unit (ICU) and dermatology services. Notably, isolates from the surgical ICU were the least susceptible to fluconazole (86.3%). There was no evidence of increasing azole resistance over time among C. parapsilosis isolates tested from 2001 to 2005. Of BSI isolates tested against the three echinocandins, 92, 99, and 100% were inhibited by concentrations of ?2 μg/ml of anidulafungin (621 isolates tested), caspofungin (1,447 isolates tested), and micafungin (539 isolates tested), respectively. C. parapsilosis is a ubiquitous pathogen that remains susceptible to the azoles and echinocandins; however, both the frequency of isolation and the resistance of C. parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service. Copyright ? 2008, American Society for Microbiology. All Rights Reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-40749148116&doi=10.1128%2fJCM.02122-07&partnerID=40&md5=91debfdee306b2b5c5eda1485c9919f5 https://scholars.lib.ntu.edu.tw/handle/123456789/535999 |
ISSN: | 0095-1137 | DOI: | 10.1128/JCM.02122-07 | SDG/關鍵字: | anidulafungin; caspofungin; echinocandin; fluconazole; micafungin; pyrrole derivative; voriconazole; Africa; antifungal susceptibility; article; Candida parapsilosis; controlled study; fungus isolation; health survey; in vitro study; Middle East; minimum inhibitory concentration; nonhuman; North America; priority journal; South and Central America; Africa; Antifungal Agents; Asia; Candida; Candidiasis; Drug Resistance, Fungal; Echinocandins; Europe; Fluconazole; Fungemia; Humans; Latin America; Microbial Sensitivity Tests; Middle East; North America; Population Surveillance; Pyrimidines; Triazoles; World Health; Candida; Candida parapsilosis |
顯示於: | 醫學系 |
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