https://scholars.lib.ntu.edu.tw/handle/123456789/536176
標題: | Risk factors affecting in-hospital mortality in patients with nosocomial infections | 作者: | WANG-HUEI SHENG JANN-TAY WANG Lin M.-S. SHAN-CHWEN CHANG |
公開日期: | 2007 | 出版社: | Scientific Communications International Ltd | 卷: | 106 | 期: | 2 | 起(迄)頁: | 110-118 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: Nosocomial infection (NI)-associated death is an important issue for both patients and clinicians, and is of emerging importance in public health. This study investigated the factors associated with in-hospital deaths among patients with NI. Methods: Between July 1, 2002 and June 30, 2003, a total of 1574 patients with NI at National Taiwan University Hospital were enrolled to investigate the factors associated with fatal outcome. Host factors, hospital services, surgical and medical interventions, microbial factors, infection sites, and the treatment and complications of NI were analyzed retrospectively. Results: During the study period, 554 of the 1574 patients died (mortality rate, 28.3%). NI was directly involved in 80.5% of them (n = 446), and over two-thirds (67.9%) of deaths occurred within 2 weeks of NI onset. Sixteen variables were statistically implicated as independent factors significantly associated with mortality. Host factors included higher disease severity (p < 0.0001), liver cirrhosis (p < 0.0001), solid tumors (p < 0.0001), chronic lung disease (p = 0.003), and congestive heart failure (p = 0.005). Hospital and interventional factors included intensive care hospitalization (p = 0.002), longer hospitalization before NI onset (p = 0.004), hemodialysis (p = 0.0003), arterial-line insertion (p < 0.0001), urinary catheterization (p < 0.0001), and central venous catheterization (p = 0.001). Blood stream infections (p < 0.0001), NI due to Candida (p < 0.0001), and multiple (? 2) episodes of NI (p < 0.0001) were significant risk factors for death, as were occurrence of NI-associated septic shock (p < 0.0001) and disseminated intravascular coagulation (p < 0.0001). No significant associations of mortality with age, sex, species of bacteria, multi-antibiotic resistant bacteria, regimen for initial treatment, or multiple antibiotic therapy were evident. Conclusion: Measures that prevent the occurrence of NI, such as improving the immunity status of the host, removal of catheters as soon as possible, and implementing an infection control program, could reduce the risk of in-hospital deaths attributable to NI. ? 2007 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847781156&doi=10.1016%2fS0929-6646%2809%2960226-6&partnerID=40&md5=c9a25d690655a90f7c1c9ddd038fbfab https://scholars.lib.ntu.edu.tw/handle/123456789/536176 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60226-6 | SDG/關鍵字: | antineoplastic agent; immunosuppressive agent; steroid; antibiotic resistance; artery catheterization; article; Candida; catheterization; central venous catheterization; chronic lung disease; congestive heart failure; device removal; disease severity; fatality; hemodialysis; hospital infection; hospital service; host resistance; human; immune response; immune status; infection control; intensive care; length of stay; liver cirrhosis; major clinical study; medical care; mortality; nonhuman; risk factor; risk reduction; septicemia; solid tumor; statistical significance; surgery; Taiwan; university hospital |
顯示於: | 醫學系 |
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