https://scholars.lib.ntu.edu.tw/handle/123456789/536233
標題: | Dengue type 3 virus in plasma is a population of closely related genomes: Quasispecies | 作者: | Wang W.-K. Lin S.-R. Lee C.-M. King C.-C. SHAN-CHWEN CHANG |
公開日期: | 2002 | 卷: | 76 | 期: | 9 | 起(迄)頁: | 4662-4665 | 來源出版物: | Journal of Virology | 摘要: | Using reverse transcription-PCR and clonal sequencing of the dengue virus envelope gene derived from the plasma samples of six patients, we reported for the first time that dengue virus circulates as a population of closely related genomes. The extent of sequence diversity varied among patients, with the mean pairwise proportions of difference ranging from 0.21 to 1.67%. Genome-defective viruses were found in 5.8% of the total number of clones analyzed. Our findings on the quasispecies nature of dengue virus and the defective virus in vivo have implications with regard to the pathogenesis of dengue virus. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036229533&doi=10.1128%2fJVI.76.9.4662-4665.2002&partnerID=40&md5=afd3fd5264d5dd0cc8111ecd745a2318 https://scholars.lib.ntu.edu.tw/handle/123456789/536233 |
ISSN: | 0022-538X | DOI: | 10.1128/JVI.76.9.4662-4665.2002 | SDG/關鍵字: | article; controlled study; Dengue virus; envelope gene; gene sequence; genetic variability; human; molecular cloning; nonhuman; nucleotide sequence; plasma; priority journal; reverse transcription polymerase chain reaction; sequence analysis; virus envelope; virus genome; virus pathogenesis; Amino Acid Sequence; Dengue; Dengue Virus; Genome, Viral; Humans; Molecular Sequence Data; RNA, Viral; Sequence Analysis, DNA; Variation (Genetics); Viral Envelope Proteins |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。