https://scholars.lib.ntu.edu.tw/handle/123456789/536274
標題: | Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: Association with hospital antimicrobial usage | 作者: | Su C.-H. JANN-TAY WANG Hsiung C.A. Chien L.-J. Chi C.-L. Yu H.-T. Chang F.-Y. SHAN-CHWEN CHANG |
公開日期: | 2012 | 卷: | 7 | 期: | 5 | 起(迄)頁: | e37788 | 來源出版物: | PLoS ONE | 摘要: | Objective: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as an important pathogen causing healthcare-associated infections (HAIs) in Taiwan. The present study is aimed to investigate the epidemiology of HAIs caused by CRAB and the association of CRAB infection and hospital usage of different antimicrobials. Methods: Two nationwide databases in the period 2003 to 2008, the Taiwan Nosocomial Infection Surveillance System and National Health Insurance claim data, were used for analysis. A total of 13,811 healthcare-associated A. baumannii infections and antimicrobial usage data from 121 hospitals were analyzed. Results: There was a significant increase in the proportion of number of HAIs caused by CRAB over that by all A. baumannii (CRABpAB), from 14% in 2003 to 46% in 2008 (P<0.0001). The greatest increase was in central Taiwan, from 4% in 2003 to 62% in 2008 (P<0.0001). Use of anti-pseudomonal carbapenems, but not other classes of antibiotics, was significantly correlated with the increase of CRABpAB (r = 0.86, P<0.0001). Conclusions: We suggested that dedicated use of anti-pseudomonal carbapenems would be an important intervention to control the increase of CRABpAB. ? 2012 Su et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861324067&doi=10.1371%2fjournal.pone.0037788&partnerID=40&md5=e51e4ca79a9db45be8a299eab5633bcd https://scholars.lib.ntu.edu.tw/handle/123456789/536274 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0037788 | SDG/關鍵字: | amikacin; carbapenem derivative; cefepime; cefoperazone; cefpirome; ceftazidime; cilastatin plus imipenem; ciprofloxacin; gentamicin; isepamicin; levofloxacin; meropenem; netilmicin; piperacillin plus tazobactam; timentin; tobramycin; Acinetobacter infection; article; carbapenem resistant Acinetobacter baumannii infection; data base; demography; drug use; emergency care; epidemiological data; hospital; human; length of stay; major clinical study; Taiwan; Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Carbapenems; Cross Infection; Databases, Factual; Drug Resistance, Bacterial; Hospitals; Humans; Incidence; Prevalence; Taiwan; Acinetobacter baumannii |
顯示於: | 醫學系 |
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