https://scholars.lib.ntu.edu.tw/handle/123456789/536314
標題: | National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential | 作者: | Hsieh Y.-C. Lin P.-Y. Chiu C.-H. Huang Y.-C. Chang K.-Y. Liao C.-H. Chiu N.-C. Chuang Y.-C. Chen P.-Y. SHAN-CHWEN CHANG Liu J.-W. Yen M.-Y. Wang J.-H. Liu C.-Y. Lin T.-Y. |
關鍵字: | Invasive pneumococcal diseases; Invasive potential; Serotype 19A | 公開日期: | 2009 | 卷: | 27 | 期: | 40 | 起(迄)頁: | 5513-5518 | 來源出版物: | Vaccine | 摘要: | We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ?5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ?5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ?65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed. ? 2009. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68549095936&doi=10.1016%2fj.vaccine.2009.06.091&partnerID=40&md5=aff676d9b89fa90c8ada4097388a1134 https://scholars.lib.ntu.edu.tw/handle/123456789/536314 |
ISSN: | 0264-410X | DOI: | 10.1016/j.vaccine.2009.06.091 | SDG/關鍵字: | Pneumococcus vaccine; adolescent; adult; aged; article; bacterial colonization; child; female; health survey; human; major clinical study; male; pneumococcal infection; priority journal; serotype; Streptococcus pneumoniae; Taiwan; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance, Bacterial; Humans; Incidence; Infant; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Population Surveillance; Prospective Studies; Serotyping; Streptococcus pneumoniae; Taiwan; Vaccines, Conjugate; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。