https://scholars.lib.ntu.edu.tw/handle/123456789/536487
標題: | Cardiac mechanics and ventricular twist by three-dimensional strain analysis in relation to B-type natriuretic peptide as a clinical prognosticator for heart failure patients | 作者: | SHENG-NAN CHANG Lai Y.-H. Yen C.-H. CHIA-TI TSAI JOU-WEI LIN Bulwer B.E. Hung T.-C. Hou C.J.-Y. Kuo J.-Y. Hung C.-L. HWANG, JUEY-JEN Yeh H.-I. |
公開日期: | 2014 | 出版社: | Public Library of Science | 卷: | 9 | 期: | 12 | 來源出版物: | PLoS ONE | 摘要: | Background: Three dimensional (3D) echocardiography-derived measurements of myocardial deformation and twist have recently advanced as novel clinical tools. However, with the exception of left ventricular ejection fraction and mass quantifications in hypertension and heart failure populations, the prognostic value of such imaging techniques remains largely unexplored. Methods: We studied 200 subjects (mean age: 60.2±16 years, 54% female, female n=107) with known hypertension (n=51), diastolic heart failure (n=61), or systolic heart failure (n=30), recruited from heart failure outpatient clinics. Fiftyeight healthy volunteers were used as a control group. All participants underwent 3D-based myocardial deformation and twist analysis (Artida, Toshiba Medical Systems, Tokyo, Japan). We further investigated associations between these measures and brain natriuretic peptide levels and clinical outcomes. Results: The global 3D strain measurements of the healthy, hypertension, diastolic heart failure, and systolic heart failure groups were 28.03%, 24.43%, 19.70%, and 11.95%, respectively (all p<0.001). Global twist measurements were estimated to be 9.49°, 9.77°, 8.32°, and 4.56°, respectively. We observed significant differences regarding 3D-derived longitudinal, radial, and global 3D strains between the different disease categories (p<0.05), even when age, gender, BMI and heart rate were matched. In addition, 3D-derived longitudinal, circumferential, and 3D strains were all highly correlated with brain natriuretic peptide levels (p<0.001). At a mean 567.7 days follow-up (25th-75th IQR: 197-909 days), poorer 3D-derived longitudinal, radial, and global 3D strain measurements remained independently associated with a higher risk of cardiovascular related death or hospitalization due to heart failure, after adjusting for age, gender, and left ventricular ejection fraction (all p<0.05). Conclusions: 3D-based strain analysis may be a feasible and useful diagnostic tool for discriminating the extent of myocardial dysfunction. Furthermore, it is able to provide a prognostic value beyond traditional echocardiographic parameters in terms of ejection fraction. ? 2014 Chang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920180800&doi=10.1371%2fjournal.pone.0115260&partnerID=40&md5=4ddf2776164ec8c71d465127de17b250 https://scholars.lib.ntu.edu.tw/handle/123456789/536487 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0115260 | SDG/關鍵字: | brain natriuretic peptide; biological marker; brain natriuretic peptide; adult; age; Article; biomechanics; body mass; controlled study; death; diagnostic test accuracy study; diastolic heart failure; female; gender; heart failure; heart function; heart left ventricle ejection fraction; heart rate; hospitalization; human; hypertension; major clinical study; male; middle aged; prognosis; protein blood level; receiver operating characteristic; retrospective study; risk factor; sensitivity and specificity; systolic heart failure; three dimensional echocardiography; ultrasound scanner; ultrasound transducer; aged; blood; case control study; Doppler echocardiography; echography; evaluation study; heart failure; heart ventricle function; three dimensional echocardiography; Adult; Aged; Biomarkers; Case-Control Studies; Echocardiography, Doppler; Echocardiography, Three-Dimensional; Female; Heart Failure; Humans; Hypertension; Male; Middle Aged; Natriuretic Peptide, Brain; Ventricular Function |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。