https://scholars.lib.ntu.edu.tw/handle/123456789/536822
標題: | Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study | 作者: | Sobrin, Lucia Chong, Yong He Fan, Qiao Gan, Alfred Stanwyck, Lynn K Kaidonis, Georgia Craig, Jamie E Kim, Jihye Liao, Wen-Ling Huang, Yu-Chuen Lee, Wen-Jane Hung, Yi-Jen Guo, Xiuqing Hai, Yang Ipp, Eli Pollack, Samuela Hancock, Heather Price, Alkes Penman, Alan Mitchell, Paul Liew, Gerald Smith, Albert V Gudnason, Vilmundur Tan, Gavin Klein, Barbara E K Kuo, Jane Li, Xiaohui Christiansen, Mark W Psaty, Bruce M Sandow, Kevin Jensen, Richard A Klein, Ronald Cotch, Mary Frances Wang, Jie Jin Jia, Yucheng Chen, Ching J Chen, Yii-Der Ida Rotter, Jerome I Tsai, Fuu-Jen Hanis, Craig L Burdon, Kathryn P Wong, Tien Yin Cheng, Ching-Yu JYH-MING JIMMY JUANG |
公開日期: | 2017 | 卷: | 66 | 期: | 12 | 來源出版物: | Diabetes | 摘要: | Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/536822 | ISSN: | 0012-1797 1939-327X |
DOI: | 10.2337/db17-0398 |
顯示於: | 醫學系 |
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