https://scholars.lib.ntu.edu.tw/handle/123456789/537013
標題: | Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students | 作者: | Chen C.-Y. HONG-YUAN HSU Liu C.-C. MEI-HWEI CHANG YEN-HSUAN NI |
公開日期: | 2010 | 卷: | 28 | 期: | 34 | 起(迄)頁: | 5605-5608 | 來源出版物: | Vaccine | 摘要: | Background: This study is aimed to investigate if there was increased risk of HBV acquisition among first graders in Taiwan during a 3-year follow-up period. Methods: A total of 1545 healthy first graders, who were vaccinated against HBV in infancy, were recruited in 2005. All subjects were checked for hepatitis B surface antigens (HBsAg), antibodies to HBsAg (anti-HBs), and to the hepatitis B core antigen (anti-HBc). Nucleotide sequence of the " a" determinant of HBsAg was determined by polymerase chain reaction and direct sequencing in the HBsAg carriers. Results: Among 1545 subjects, 0.78% were HBsAg seropositive, 54.30% were anti-HBs seropositive, and 1.68% anti-HBc seropositive. Three of the 10 HBV carriers (30%), whose HBV DNA were sequenced for the S gene, had surface antigen mutants at the " a" determinant. Conclusion: There were no new chronic HBV infections in this cohort of children for two consecutive years. HBV S gene vaccine escape mutants did exist in the vaccine-failure population, but they may not have made a major health impact. ? 2010 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955056692&doi=10.1016%2fj.vaccine.2010.06.029&partnerID=40&md5=d73d3b190e859a8d4551fd34b234508b https://scholars.lib.ntu.edu.tw/handle/123456789/537013 |
ISSN: | 0264-410X | DOI: | 10.1016/j.vaccine.2010.06.029 | SDG/關鍵字: | hepatitis B antibody; hepatitis B core antigen; hepatitis B surface antigen; virus DNA; hepatitis B antibody; hepatitis B core antigen; hepatitis B surface antigen; hepatitis B vaccine; virus DNA; article; cohort analysis; disease surveillance; DNA sequence; female; follow up; gene; hepatitis B; Hepatitis B virus; human; human experiment; immunization; male; normal human; nucleotide sequence; polymerase chain reaction; primary school; priority journal; questionnaire; risk factor; seroepidemiology; Taiwan; virus carrier; blood; child; genetics; hepatitis B; heterozygote; Carrier State; Child; DNA, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Male; Seroepidemiologic Studies; Taiwan; Carrier State; Child; DNA, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Male; Seroepidemiologic Studies; Taiwan |
顯示於: | 醫學系 |
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