https://scholars.lib.ntu.edu.tw/handle/123456789/537082
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JIA-FENG WU | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | Hsieh R.-P. | en_US |
dc.contributor.author | Shih H.-H. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | Li C.-R. | en_US |
dc.contributor.author | Chiang C.-Y. | en_US |
dc.contributor.author | Shau W.-Y. | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.date.accessioned | 2021-01-04T07:36:15Z | - |
dc.date.available | 2021-01-04T07:36:15Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-3476 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646833969&doi=10.1016%2fj.jpeds.2005.12.025&partnerID=40&md5=a5723b679bcea650ad18b2b7f526e851 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537082 | - |
dc.description.abstract | Objective: To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen (HBeAg). Study design: In the prospective cohort study, 81 HBeAg-positive children with chronic hepatitis B virus (HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ± 3.23 years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship. Results: HLA-B61 and HLA-DQB1*0503 antigens predicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22, P = .024 and .017, respectively). Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen. Conclusions: HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwanese children with chronic HBV infection. ? 2006 Elsevier Inc. All rights reserved. | - |
dc.publisher | Mosby Inc. | - |
dc.relation.ispartof | Journal of Pediatrics | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; hepatitis B antigen; HLA DQB1 antigen; adolescent; adult; article; child; chronic hepatitis; controlled study; DNA polymorphism; female; follow up; hepatitis B; HLA typing; human; infant; long term care; major clinical study; male; priority journal; seroconversion; sibling; Taiwan | - |
dc.title | HLA typing associated with hepatitis B E antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jpeds.2005.12.025 | - |
dc.identifier.pmid | 16737879 | - |
dc.identifier.scopus | 2-s2.0-33646833969 | - |
dc.relation.pages | 647-651 | - |
dc.relation.journalvolume | 148 | - |
dc.relation.journalissue | 5 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0001-6343-1658 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
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