https://scholars.lib.ntu.edu.tw/handle/123456789/537166
標題: | Steroids used to desensitize penicillamine allergy in Wilson disease | 作者: | Hsu H.-L. Huang F.-C. YEN-HSUAN NI MEI-HWEI CHANG |
公開日期: | 1999 | 卷: | 40 | 期: | 6 | 起(迄)頁: | 448-450 | 來源出版物: | Acta Paediatrica Taiwanica | 摘要: | Patients with Wilson disease require life-long treatment and penicillamine is the drug of choice. We present a 14-year-old boy with Wilson disease who developed hypersensitivity reaction 2 days after starting penicillamine therapy. His symptoms included fever, maculopapular rash and lip edema. The allergic reaction disappeared when penicillamine was discontinued, but relapsed after reinstituting penicillamine at a lower dose. Desensitization was attempted by introducing steroid therapy, the dose of 0.7 mg per kilogram per day of prednisolone for 2 days, then penicillamine was successfully tolerated. Subsequent tapering of the daily prednisolone dose was performed till it was discontinued one month after treatment began. We suggest that concomitant use of steroid and penicillamine should be used for the treatment of patients who develop penicillamine intolerance. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033491315&partnerID=40&md5=00482485f4e055c0370dce1f98c51dc3 https://scholars.lib.ntu.edu.tw/handle/123456789/537166 |
ISSN: | 0001-6578 | SDG/關鍵字: | penicillamine; prednisolone; steroid; adolescent; aplastic anemia; article; case report; corticosteroid therapy; desensitization; drug hypersensitivity; hemolytic anemia; human; male; myasthenia gravis; nephrotic syndrome; thrombocytopenia; treatment outcome; Wilson disease; Adolescent; Drug Hypersensitivity; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Prednisolone |
顯示於: | 醫學系 |
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