https://scholars.lib.ntu.edu.tw/handle/123456789/537249
標題: | Minimal role of hepatitis C virus infection in childhood liver diseases in an area hyperendemic for hepatitis B infection | 作者: | MEI-HWEI CHANG CHIN-YUN LEE DING-SHINN CHEN |
關鍵字: | enzyme immunoassay for anti?HCV; hepatitis C virus; liver disease in children; non?A; non?B hepatitis; Taiwan | 公開日期: | 1993 | 卷: | 40 | 期: | 4 | 起(迄)頁: | 322-325 | 來源出版物: | Journal of Medical Virology | 摘要: | To investigate the role of hepatitis C virus (HCV) in childhood liver disease in Taiwan, an area hyperendemic for hepatitis B, we studied antibody to HCV (anti?HCV) with a second generation enzyme immunoassay in 195 infants and children, including 96 hepatitis B surface antigen (HBsAg) positive children (66 with chronic hepatitis B, 23 children with hepatocellular carcinoma, and 7 with fulminant hepatitis B), 6 children with fulminant non?A, non?B hepatitis, 42 infants with neonatal hepatitis, 11 with biliary atresia, and 40 prospectively followed blood recipients. For comparison, another 748 apparently healthy children (from neonates to 12 years) were also screened for anti?HCV. The positive rate of anti?HCV was low in both apparently healthy children (0.13%) and patients with various liver disorders (0 to 4.4%) except fulminant hepatitis. The seropositive rate in 6 cases of non?A, non?B fulminant hepatitis was higher (16.7%) although the case number was too small. We conclude that HCV is generally not a major etiologic factor in the liver diseases of Taiwanese children. ? 1993 Wiley?Liss, Inc. Copyright ? 1993 Wiley?Liss, Inc., A Wiley Company |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027319212&doi=10.1002%2fjmv.1890400411&partnerID=40&md5=9dacb4e261bb87571be3b4f059dd0345 https://scholars.lib.ntu.edu.tw/handle/123456789/537249 |
ISSN: | 0146-6615 | DOI: | 10.1002/jmv.1890400411 | SDG/關鍵字: | article; child; controlled study; enzyme linked immunosorbent assay; hepatitis b; hepatitis c; hepatitis non a non b; human; infant; liver disease; major clinical study; priority journal; taiwan; Adolescent; Biliary Atresia; Carcinoma, Hepatocellular; Child; Child, Preschool; Hepatitis Antibodies; Hepatitis B; Hepatitis C; Human; Infant; Liver Diseases; Liver Neoplasms; Prevalence; Seroepidemiologic Studies; Support, Non-U.S. Gov't |
顯示於: | 醫學系 |
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