https://scholars.lib.ntu.edu.tw/handle/123456789/537455
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHANG-JU WU | en_US |
dc.contributor.author | Kuo Y.-Y. | en_US |
dc.contributor.author | HSIN-AN HOU | en_US |
dc.contributor.author | Li Y. | en_US |
dc.contributor.author | Tseng M.-H. | en_US |
dc.contributor.author | Huang C.-F. | en_US |
dc.contributor.author | Lee F.-Y. | en_US |
dc.contributor.author | Liu M.-C. | en_US |
dc.contributor.author | Liu C.-W. | en_US |
dc.contributor.author | Lin C.-T. | en_US |
dc.contributor.author | Chen, Chien-Yuan | en_US |
dc.contributor.author | WEN-CHIEN CHOU | en_US |
dc.contributor.author | MING YAO | en_US |
dc.contributor.author | SHANG-YI HUANG | en_US |
dc.contributor.author | BOR-SHENG KO | en_US |
dc.contributor.author | JIH-LUH TANG | en_US |
dc.contributor.author | WOEI TSAY | en_US |
dc.contributor.author | HWEI-FANG TIEN | en_US |
dc.date.accessioned | 2021-01-04T12:12:42Z | - |
dc.date.available | 2021-01-04T12:12:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867801670&doi=10.1182%2fblood-2012-02-412296&partnerID=40&md5=590690200639530d1a952690fecfdb97 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537455 | - |
dc.description.abstract | Recurrent somatic mutation of SRSF2, one of the RNA splicing machinery genes, has been identified in a substantial proportion of patients with myelodysplastic syndrome (MDS). However, the clinical and biologic characteristics of MDS with this mutation remain to be addressed. In this study, 34 (14.6%) of the 233 MDS patients were found to have SRSF2 mutation. SRSF2 mutation was closely associated with male sex (P = .001) and older age (P < .001). It occurred concurrently with at least 1 additional mutation in 29 patients (85.3%) and was closely associated with RUNX1, IDH2, and ASXL1 mutations (P = .004, P < .001, and P < .001, respectively). Patients with SRSF2 mutation had an inferior overall survival (P = .010), especially in the lower risk patients. Further exploration showed that the prognostic impact of SRSF2 mutation might be attributed to its close association with old age. Sequential analyses in 173 samples from 66 patients showed that all SRSF2-mutated patients retained their original mutations, whereas none of the SRSF2-wild patients acquired a novel mutation during disease evolution. In conclusion, SRSF2 mutation is associated with distinct clinical and biologic features in MDS patients. It is stable during the clinical course and may play little role in disease progression. ? 2012 by The American Society of Hematology. | - |
dc.relation.ispartof | Blood | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ASXL1 protein; isocitrate dehydrogenase 2; mixed lineage leukemia protein; SRSF2 protein; transcription factor RUNX1; unclassified drug; adult; aged; aging; article; controlled study; disease course; female; gene mutation; genetic association; genetic risk; human; human cell; major clinical study; male; myelodysplastic syndrome; overall survival; priority journal; prognosis; RNA splicing; sequence analysis; somatic mutation | - |
dc.title | The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1182/blood-2012-02-412296 | - |
dc.identifier.pmid | 22932795 | - |
dc.identifier.scopus | 2-s2.0-84867801670 | - |
dc.relation.pages | 3106-3111 | - |
dc.relation.journalvolume | 120 | - |
dc.relation.journalissue | 15 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-0772-869X | - |
crisitem.author.orcid | 0000-0003-2780-4845 | - |
crisitem.author.orcid | 0000-0003-2831-8822 | - |
crisitem.author.orcid | 0000-0003-2967-698X | - |
crisitem.author.orcid | 0000-0003-2932-0019 | - |
crisitem.author.orcid | 0000-0001-5688-3410 | - |
crisitem.author.orcid | 0000-0002-7965-7579 | - |
crisitem.author.orcid | 0000-0003-4021-3281 | - |
crisitem.author.orcid | 0000-0001-6244-3868 | - |
crisitem.author.orcid | 0000-0002-1384-5593 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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