https://scholars.lib.ntu.edu.tw/handle/123456789/537519
標題: | Chromosomal abnormalities of 200 Chinese patients with non-Hodgkins's lymphoma in Taiwan: With special reference to T-cell lymphoma | 作者: | Chen, Chien-Yuan MING YAO JIH-LUH TANG WOEI TSAY Wang C.-C. WEN-CHIEN CHOU Su I.-J. Lee F.-Y. Liu M.-C. HWEI-FANG TIEN |
公開日期: | 十一月-2004 | 卷: | 15 | 期: | 7 | 起(迄)頁: | 1091-1096 | 來源出版物: | Annals of Oncology | 摘要: | Background: The distribution of the histopathological subtypes of non-Hodgkin's lymphoma (NHL) is different among various geographical areas. However, there are few reports concerning cytogenetic findings of NHL, especially T-cell lymphoma, in Asian people. Patients and methods: We analyzed the chromosomal abnormalities of 200 adult patients with NHL in Taiwan and correlated the non-random aberrations with the histological subtypes. Results: One hundred and thirty-eight patients (69%) had B-cell lymphoma. The incidence of the t(14;18) in total lymphoma was lower in Taiwan (12%) than in the West (20-30%), but its incidence in follicular lymphoma was comparable between the two areas (17 of 28 patients, 61% versus ?50-60%). Sixty-two patients (31%) had T-cell lymphoma, including 11 angiocentric T/natural killer (NK)-cell lymphoma and only two angioimmunoblastic T-cell lymphoma (AILD). The recurrent chromosomal abnormalities in T-cell lymphoma comprised 6q deletion (30%), 11q deletion (20%), 17p deletion (16%), -17 (16%), -Y (14%) and + 8 (11%). Angiocentric T/NK-cell lymphoma had a significantly higher frequency of 1q duplication (P=0.001), 6p duplication (P<0.001) and 11q deletion (P = 0.011) than other T-cell lymphoma. The incidences of + 3 and + 5, two common abnormalities in AILD, were quite low in T-cell lymphoma in Taiwan (4% and 2%, respectively), compared with those in the West (16-32% and ?15%, respectively). The 11q deletion, not a common aberration in T-cell lymphoma in western countries, occurred quite frequently in Taiwan. Conclusions: The chromosomal aberrations of NHL are quite different among various geographical areas, which may reflect the differences in the distribution of the histological subtypes of lymphoma among various areas. ? 2004 European Society for Medical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4143051390&doi=10.1093%2fannonc%2fmdh263&partnerID=40&md5=f95ed8daf7085d4018f6eb92a0deb20d https://scholars.lib.ntu.edu.tw/handle/123456789/537519 |
ISSN: | 0923-7534 | DOI: | 10.1093/annonc/mdh263 | SDG/關鍵字: | adult; aged; article; Asia; B cell lymphoma; cancer classification; cancer incidence; cancer recurrence; Chinese; chromosome 11q; chromosome 17p; chromosome 1q; chromosome 6p; chromosome aberration; chromosome duplication; controlled study; correlation analysis; cytogenetics; ethnic difference; gene deletion; geographic distribution; histopathology; human; human tissue; major clinical study; natural killer cell; nonhodgkin lymphoma; priority journal; T cell lymphoma; Adult; Aged; Aged, 80 and over; Bone Marrow Cells; Chromosome Aberrations; Chromosome Deletion; Gene Duplication; Humans; Karyotyping; Lymph Nodes; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Middle Aged; Taiwan |
顯示於: | 醫學系 |
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