https://scholars.lib.ntu.edu.tw/handle/123456789/537560
標題: | Phenytoin-induced pseudolymphoma: Reevaluation using modern molecular biology techniques | 作者: | YUNG-MING JENG HWEI-FANG TIEN Su I.-J. |
公開日期: | 1996 | 卷: | 37 | 期: | 1 | 起(迄)頁: | 104-107 | 來源出版物: | Epilepsia | 摘要: | Patients receiving phenytoin (PHT) may develop pseudolymphoma or, rarely, malignant lymphoma. Previously, distinguishing the two diseases based solely on histopathology has been difficult. The recent introduction of molecular biological techniques has provided a powerful tool to reassess this problem. A 17-year-old girl developed systemic lymphadenopathy after receiving PHT for 1 year for generalized tonic-clonic seizures (GTCS). Biopsy of a cervical lymph node showed diffuse proliferation of large lymphoid cells mimicking a large cell lymphoma. Immunophenotypic, immunoglobulin gene rearrangement, and cytogenetic studies, however, showed polyclonal B-cell proliferation, consistent with PHT-induced pseudolymphoma. After PHT discontinuation, lymphadenopathy resolved in 1 month and no recurrence developed in the subsequent 10 months. Obtaining a history of drug use is crucial to recognizing this group of patients. Molecular biology and chromosome studies have become the definitive basis differentiating pseudolymphoma from malignant lymphoma in patients receiving chronic PHT therapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030050180&doi=10.1111%2fj.1528-1157.1996.tb00521.x&partnerID=40&md5=5bd1f65ca841a1d9507bc4f0f36d651b https://scholars.lib.ntu.edu.tw/handle/123456789/537560 |
ISSN: | 0013-9580 | DOI: | 10.1111/j.1528-1157.1996.tb00521.x | SDG/關鍵字: | phenytoin; adolescent; article; b lymphocyte; case report; cervical lymph node; drug withdrawal; female; grand mal epilepsy; human; human tissue; lymph node biopsy; lymphadenopathy; lymphocyte proliferation; priority journal; pseudolymphoma; Adolescent; Biopsy; Blotting, Southern; Chromosome Aberrations; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Female; Gene Rearrangement, B-Lymphocyte; Humans; Immunophenotyping; Lymphoma; Phenytoin |
顯示於: | 醫學系 |
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