https://scholars.lib.ntu.edu.tw/handle/123456789/537571
標題: | Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity | 作者: | Wang C.‐C. HWEI-FANG TIEN Lin M.‐T. Su I.‐J. Wang C.‐H. Chuang S.‐M. MING-CHING SHEN Liu C.‐H. |
公開日期: | 1995 | 卷: | 12 | 期: | 3 | 起(迄)頁: | 161-164 | 來源出版物: | Genes, Chromosomes and Cancer | 摘要: | Peripheral T?cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T?cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non?Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL. Copyright ? 1995 Wiley?Liss, Inc., A Wiley Company |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028945858&doi=10.1002%2fgcc.2870120302&partnerID=40&md5=5ac61be3807dd66f3a30111a79110c9a https://scholars.lib.ntu.edu.tw/handle/123456789/537571 |
ISSN: | 1045-2257 | DOI: | 10.1002/gcc.2870120302 | SDG/關鍵字: | t lymphocyte receptor; adult; article; cancer genetics; case report; chromosome 7q; chromosome analysis; clinical examination; human; isochromosome; liver tumor; male; priority journal; spleen tumor; t cell lymphoma; trisomy 8; Adult; Antigens, CD; Bone Marrow; Case Report; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Fatal Outcome; Genetic Markers; Human; Isochromosomes; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Male; Receptors, Antigen, T-Cell, gamma-delta; Spleen; Splenic Neoplasms; Support, Non-U.S. Gov't; Trisomy |
顯示於: | 醫學系 |
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