https://scholars.lib.ntu.edu.tw/handle/123456789/537579
標題: | Characterization of acute myeloid leukemia (AML) coexpressing lymphoid markers: Different biologic features between T-cell antigen positive and B-cell antigen positive AML | 作者: | HWEI-FANG TIEN Wang C.-H. YAO-CHANG CHEN MING-CHING SHEN Lin D.-T. KAI-HSIN LIN |
公開日期: | 1993 | 出版社: | Nature Publishing Group | 卷: | 7 | 期: | 5 | 起(迄)頁: | 688-695 | 來源出版物: | Leukemia | 摘要: | The clinical and biologic characteristics of acute myeloid leukemia (AML) with coexpression of lymphoid-associated antigens (Lym+AML) were studied from 39 cases who represented 24% of 161 newly diagnosed de novo AML. Twenty-seven cases (16.8%) were positive for the expression of T-cell markers (T+AML) and 12 (7.5%) for B-cell markers (B+AML). Chromosomal abnormalities t(9;22)(q34;q11) and t/del(11)(q23), which were considered to be associated with acute leukemia coexpressing markers of more than one cell lineage, were detected in five and in four patients, respectively. There was no prognostic significance of B-cell or T-cell antigen expression in AML. Of 12 T+AML cases in which cells were available for gene analysis, all showed germline configuration of immunoglobulin heavy chain and T-cell receptor β chain genes, while seven of nine B+ AML showed rearrangements of either or both of the genes. Double labeling of the cells with myeloperoxidase and lymphoid markers demonstrated that individual blasts in all the five T+AML tested were simultaneously expressing myeloperoxidase activity and CD7; however, most blasts in the three B+AML studied expressed either myeloperoxidase activity or CD10, but not both. In eight of the nine T+AML tested, the T-cell antigen-positive leukemic blasts were significantly decreased to less than 10%, after in vitro culture with the differentiation-inducing agent phorbol ester. B-cell markers remained positive (?20%) on the cells in the two B+AML who had the same study. These findings suggested that T+AML and B+AML might have different biologic features. Further studies on more patients are needed to clarify this point. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027309285&partnerID=40&md5=3a85b47923cc0fbf298b5f415d6c276d https://scholars.lib.ntu.edu.tw/handle/123456789/537579 |
ISSN: | 0887-6924 | SDG/關鍵字: | b lymphocyte antigen; cell marker; common acute lymphoblastic leukemia antigen; immunoglobulin heavy chain; myeloperoxidase; phorbol ester; t lymphocyte antigen; acute granulocytic leukemia; adolescent; adult; article; b cell leukemia; blast cell; cell differentiation; child; chromosome 11q; chromosome aberration; chromosome deletion; chromosome translocation 22; chromosome translocation 9; female; gene rearrangement; human; human cell; immunoglobulin gene; infant; lymphoid cell; male; priority journal; prognosis; t cell leukemia; t lymphocyte receptor gene; Acute Disease; Adolescent; Adult; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Antigens, Differentiation, T-Lymphocyte; Cell Differentiation; Child; Child, Preschool; Chromosome Banding; DNA, Neoplasm; Female; Gene Rearrangement; Genes, Immunoglobulin; Human; Immunophenotyping; In Vitro; Infant; Leukemia, Myeloid; Male; Middle Age; Prognosis; Receptors, Antigen, T-Cell, alpha-beta; Support, Non-U.S. Gov't; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。